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Neurofibromatosis type 1 (NF1) is one of the most frequent genetic disorders, affecting 1:3,000 worldwide. Identification of genotype-phenotype correlations is challenging because of the wide range clinical variability, the progressive nature of the disorder, and extreme diversity of the mutational spectrum. We report 136 individuals with a distinct(More)
Prions, which cause chronic wasting disease and other transmissible spongiform encephalopathies in ungulates, can remain active in soils for years. The reproductive age of ungulate populations is well within the residence time of prions in the soil. Reproduction and mortality in disease-free wildlife populations is regulated by density-dependent mechanisms,(More)
Acknowledgements I would like to take this opportunity to thank Dr. John Greene. As an algebra professor, he made a great impact on my growth as a young mathematician. I am grateful for his guidance in my research and his advice on career-shaping decisions. been great mentors throughout my undergraduate and graduate careers at the University of Minnesota(More)
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