Angela R. Kamps

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BACKGROUND G protein-coupled receptors (GPCRs) play central roles in mediating cellular responses to environmental signals leading to changes in cell physiology and behaviors, including cell migration. Numerous clinical pathologies including metastasis, an invasive form of cell migration, have been linked to abnormal GPCR signaling. While the structures of(More)
Recognition of external conditions and the elicitation of appropriate responses are critical to a cell's ability to adjust to various developmental and environmental cues. G protein-coupled receptors (GPCRs) are a large class of receptors that act to relay external information into the cell by initiating signaling pathways that allow the cell to adapt to(More)
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