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  • C. Sotelo, A. Privat
  • 1978
Over the past 6 years we have attempted to identify some of the factors which govern the sequence of events, occurring during the establishment of the specifically ordered connectivity which characterizes neuronal networks. At the level of a single neuron, the first question that one can then ask is to what extent the moulding of its synaptic connectivity(More)
  • A. Yakovleff, J. -M. Cabelguen, +5 authors A. Privat
  • 1995
The present study was designed to examine the effects of an intraspinal transplantation of embryonic brainstem neurons on fictive motor patterns which can develop in hindlimb nerves of adult chronic spinal rats. Seventeen adult rats were spinalized at T8-9 level and, 8 days later, a suspension of embryonic cells obtained either from the raphe region (RR,(More)
  • A. Privat, M. J. Drian, P. Mandon
  • 1973
The outgrowth of newborn rat cerebellum cultivated in the Maximow assembly was studied from the time of explanation until the end of the 1st week “in vitro”. Dynamic characteristics of migrating cells were investigated with time lapse microcinematography and with phase and interference contrast. Three types of cells were identified: bipolar fusiform cells,(More)
  • J. Valat, J. Fulcrand, A. Privat, R. Marty
  • 1978
In the course of our study on Wallerian degeneration in the young rat optic nerve after unilateral enucleation, cell proliferation was measured by quantitative radio-autography. Ninety-two newborn rats were separated into four groups which were operated at 2, 5, 8 and 20 days postnatal (key stages) respectively. In each of these groups, the animals were(More)
The expression of Calcitonin gene-related peptide (CGRP) has been demonstrated in motoneurons of several species. We have investigated in adult rats the influence of transection of the spinal cord on CGRP immunoreactivity of motoneurons located below the section. Quantative analysis has been performed with computer-assisted image analysis. As early as 48 h(More)
Adjuvant-induced arthritis has been produced in adult rats in order to study the reorganization of serotonergic innervation in the spinal cord dorsal horn in a model of chronic pain. Immunocytochemical detection of CGRP and substance P was quantified with an image analyzer, and we found a transient increase for both peptides at 1 and 2 months, followed by a(More)
  • J. Valat, A. Privat, J. Fulcrand
  • 1983
In order to establish a firm basis for our studies on cell reactivity during Wallerian degeneration in the optic nerve of the rat, gliogenesis in this fiber tract was reassessed. Rats aged 2, 5, 8 and 20 days (key-stages) received a single injection of tritiated thymidine and were sacrificed after a survival period of 1, 3, 5, 10 and 20 days. Before the 5th(More)
PSA (Promastigote Surface Antigen) belongs to a family of membrane-bound and secreted proteins present in several Leishmania (L.) species. PSA is recognized by human Th1 cells and provides a high degree of protection in vaccinated mice. We evaluated humoral and cellular immune responses induced by a L. amazonensis PSA protein (LaPSA-38S) produced in a L.(More)
  • G. Guéneau, J. Drouet, A. Privat, L. Court
  • 1979
Adult rabbits were subjected to 4.5 Gy of whole-body or brain alone γ-irradiation, and their hippocampus was examined with the light and electron microscope. Pycnotic cells were found at the base of the granular layer of the dentate gyrus in the so-called subgranular zone, as soon as 3 h after irradiation, and were cleared up by active phagocytosis after 48(More)
  • T. Maurice, T. -P. Su, D. W. Parish, A. Privat
  • 2005
The high selectivity of the phencyclidine derivative PRE-084 for sigma (σ) sites is demonstrated. We previously reported that this compound is able to markedly attenuate the impairment of learning induced in mice by the non-competitive NMDA antagonist MK-801, and the cholinergic nicotinic antagonist mecamylamine. In this study, we examined the effect of(More)