Learn More
artifactual aggregation involving CLV1.) Their intriguing hypothesis is that the CLV3 protein may in fact be the activating ligand of the CLV1 receptor kinase. This possibility is attractive in that intermolecular associations of protein kinases are known to be instigated in animal systems by the binding of ligands to cell receptors. As the authors point(More)
OBJECTIVE The purpose of this study was to determine the diagnostic accuracy of CT in detecting mandibular invasion by squamous cell carcinoma of the oral cavity. MATERIALS AND METHODS Forty-nine patients who had squamous cell carcinoma of the oral cavity that was clinically fixed to the mandible were treated with mandibulectomy. All patients underwent(More)
The 1940s and 1950s were marked by intense debates over the origin of drug resistance in microbes. Bacteriologists had traditionally invoked the notions of 'training' and 'adaptation' to account for the ability of microbes to acquire new traits. As the field of bacterial genetics emerged, however, its participants rejected 'Lamarckian' views of microbial(More)
Hypercholesterolemia attenuates endothelium-dependent vasorelaxation and augments the responses to vasoconstrictor agents. Both effects are largely due to a reduction in the release of endothelium-derived relaxing factor. Since endothelium-derived relaxing factor is now known to be nitric oxide derived from the metabolism of L-arginine, we hypothesized that(More)
The widespread adoption of radioisotopes as tools in biomedical research and therapy became one of the major consequences of the "physicists' war" for postwar life science. Scientists in the Manhattan Project, as part of their efforts to advocate for civilian uses of atomic energy after the war, proposed using infrastructure from the wartime bomb project to(More)
Rosalind Franklin is best known for her informative X-ray diffraction patterns of DNA that provided vital clues for James Watson and Francis Crick's double-stranded helical model. Her scientific career did not end when she left the DNA work at King's College, however. In 1953 Franklin moved to J. D. Bernal's crystallography laboratory at Birkbeck College,(More)
In 1953 virologist John Enders stood before the American Association of Immunologists and began his talk, Tissue Cultures in the Study of Immunity " : Retrospection and Anticipation, with an apology. " To construct a presidential address around a technique, " he said, " might perhaps be taken as indicative of infertility of mind and limited imagination. "(More)
Abir-Am, Pnina. " The discourse of physical power and biological knowledge in the 1930's: A reappraisal of the Rockefeller Foundation's 'Policy' in Molecular Biology. Physics and the emergence of molecular biology: A history of cognitive and political synergy. and Beyond: the political economy of patenting life. " Thackray, Arnold, ed. Private science :(More)