Angela M Clark

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OBJECTIVE Individuals with type 1 diabetes have decreased bone mineral density (BMD), yet the natural history and pathogenesis of osteopenia are unclear. We have previously shown that women with type 1 diabetes (aged 13-35 years) have lower BMD than community age-matched nondiabetic control subjects. We here report 2-year follow-up BMD data in this cohort(More)
The proton electrochemical gradient has been measured in old brain mitochondria isolated from 2- or 24-month-old rats with the use of different respiratory substrates. With succinate as substrate, neither the respiratory rate, membrane potential or delta pH varied with age, indicating that the dielectric strength of the mitochondrial membrane was unaltered(More)
BACKGROUND Excessive intravenous fluid prescription may play a causal role in postoperative complications following major gastrointestinal resectional surgery. The aim of this study was to investigate whether fluid and salt restriction would decrease postoperative complications compared with a more modern controlled liberal regimen. METHODS In this(More)
This past year the 160th anniversary of the discovery of nitrous oxide as an analgesic/psychotropic anesthetic by an American dentist, Horace Wells, was celebrated in Hartford, Connecticut, USA. This useful gas has been in continuous use longer than any other anesthetic agent and has withstood the test of time. Applications in clinical practice over a(More)
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