Angela K Green

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Mammographic density is a strong risk factor for breast cancer, but the underlying biology for this association is unknown. Studies suggest that vitamin D may reduce breast cancer risk and dietary vitamin D intake has been associated with reduced breast density. We conducted a case-control study nested within the Nurses' Health Study cohort consisting of(More)
BACKGROUND In this paper, we provide background and context regarding the potential for a new data-sharing platform, the Project Data Sphere (PDS) initiative, funded by financial and in-kind contributions from the CEO Roundtable on Cancer, to transform cancer research and improve patient outcomes. Given the relatively modest decline in cancer death rates(More)
Useof cancer therapies for indicationsnot approvedby theUS Food andDrugAdministration (FDA), also known as “off-label” use, is widely practiced in oncology care.1 Examples includebevacizumab inmetastaticesophageal cancer or cetuximab inmetastatic prostate cancer. In the UnitedStates,off-labeluseof10commoncancerdrugsaccounted for nearly $5 billion in costs(More)
The most direct test of functional capacity of the liver in nitrogen disposal is to stress the urea cycle with a high protein load. This has been used in the diagnosis of heterozygosity for ornithine carbamoyltransferase deficiency for many years by measuring the subsequent excretion of orotic acid in urine. Reports have shown some ambiguity in both this(More)
BACKGROUND Mitoxantrone was approved for use in metastatic castrate-resistant prostate cancer (mCRPC) based on pain palliation without observed survival benefit in a small phase III trial in 1996. To re-evaluate for possible survival benefits in a larger contemporary sample and to demonstrate analytic uses of the newly available Project Data Sphere online(More)
For patients with metastatic bladder cancer, the 5-year survival rate is only 5%, and until recently, there had been no major advances in the treatment of metastatic disease for more than 3 decades. Historically, the field of bladder cancer has been grossly underfunded and underresearched, and this in part accounts for the lack of progress in the field.(More)
OBJECTIVE The purpose of this study was to examine the relationship between usual sugar-sweetened beverage (SSB) consumption and prevalence of abnormal metabolic health across body mass index (BMI) categories. METHODS The metabolic health of 6,842 non-diabetic adults was classified using cross-sectional data from the Framingham Heart Study Offspring(More)
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