Angela Ingrassia

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Subjects with incidental Lewy body disease (iLBD) may represent the premotor stage of Parkinson's disease (PD). To elucidate molecular mechanisms underlying neuronal dysfunction and alpha-synuclein pathology in the premotor phase of PD, we investigated the transcriptome of the substantia nigra (SN) of well-characterized iLBD, PD donors and age-matched(More)
Converging evidence from genetic, pathological and experimental studies have increasingly suggested an important role for autophagy impairment in Parkinson's Disease (PD). Genetic studies have identified mutations in genes encoding for components of the autophagy-lysosomal pathway (ALP), including glucosidase beta acid 1 (GBA1), that are associated with(More)
The olfactory bulb is one of the first brain regions affected by a-synuclein pathology in Parkinson's disease (PD) and incidental Lewy body disease (iLBD), which may represent the premotor stage of PD. Using genome-wide expression profiling of the olfactory bulb of pathologically-confirmed PD, iLBD and control donors, we aimed to identify molecular(More)
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