- Full text PDF available (3)
The mechanism of action of adrenaline on cardiac contractility in rat papillary muscles containing V1 and V3 isomyosins was analyzed during barium-activated contractures at 25 degrees C by frequency domain analysis using pseudo-random binary noise-modulated perturbations. The analysis characterizes a frequency (fmin) at which dynamic stiffness of a muscle… (More)
In a previous communication, we showed that beta-adrenergic stimulation of cardiac muscles was associated with an increase in the rate of cycling of crossbridges as measured by perturbation analysis in the frequency domain. In this analysis, the frequency at which dynamic stiffness is a minimum (fmin) is taken as a measure of the rate of crossbridge… (More)
1. In attempting to consolidate the role of ventricular isomyosins in regulating the contractility of the myocardium, actomyosin ATPase and crossbridge kinetics were obtained at 24 degrees C in chemically skinned isometrically contracting cardiac muscles containing V1 and V3 isomyosins. 2. The ATPase activity was measured at various levels of Ca2+… (More)
A hand-held fully electrically powered and programmable cryoprobe for general-purpose cryosurgery and cryotherapy has been developed. By combining the technologies of thermoelectric cooling and heat pipes, the temperature at the tip of the probe can easily reach -50 to -60 degrees C. It can hold below -40 degrees C when it cools a load of 10 W at the tip.… (More)
In a previous communication, we showed that 3-adrenergic stimulation of cardiac muscle was associated with an increase in the rate of cycling of crossbridges as measured by perturbation analysis in the frequency domain. In this analysis, the frequency at which dynamic stiffness is a minimum (f.in) is taken as a measure of the rate of crossbridge cycling. In… (More)
Internal audit can not only allay external and internal concerns about appropriateness of business operations, but also help improve efficiency and the bottom line. To get an internal audit function under way, healthcare organizations need to obtain board buy-in, form an audit committee of the board, determine resources needed, perform a risk assessment,… (More)
I would like to reply to Sarah f Smithies letter 'One way to safe medicines' Oanuary 6). She suggests that a self-locking latch on the drugs trolley would prevent access by anyone except the key holder.