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Traditionally, different approaches have been used to determine the recommended dietary allowances for micronutrients, above which there is a low risk of deficiency, and safe upper levels, below which there is a negligible risk of toxicity. The advice given to risk managers has been in the form of point estimates, such as the recommended dietary allowance(More)
OBJECTIVE To identify the number of drug-disease and drug-drug interactions for exemplar index conditions within National Institute of Health and Care Excellence (NICE) clinical guidelines. DESIGN Systematic identification, quantification, and classification of potentially serious drug-disease and drug-drug interactions for drugs recommended by NICE(More)
Correspondence to: R Collins, Centre for Reviews and Dissemination, University of York, York YO10 5DD, UK; rc14@york.ac.uk . . . . . . . . . . . . . . . . . . . . . . . T his article is based on a recent issue of Effective Health Care which focused on the research evidence for the management of head and neck cancers. The bulletin is based on a series of(More)
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