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The activation of endothelium is important in recruiting neutrophils to sites of inflammation and in modulating their function. We demonstrate that conditioned medium from cultured, activated endothelial cells acts to significantly delay the constitutive apoptosis of neutrophils, resulting in their enhanced survival and increased phagocytic function. The(More)
The activation of endothelium is important in recruiting neutrophils to sites of inflammation and in modulating their function. We demonstrate that conditioned medium from cultured, activated endothelial cells acts to significantly delay the constitutive apoptosis of neutrophils, resulting in their enhanced survival and increased phagocytic function. The(More)
BACKGROUND AND PURPOSE Macrophage-1 antigen (Mac-1) (CD11b/CD18), a leukocyte beta2 integrin, facilitates neutrophil adhesion, transendothelial migration, phagocytosis, and respiratory burst, all of which may mediate reperfusion-induced injury to ischemic brain tissue in conditions such as stroke. To determine the role of Mac-1 during ischemia and(More)
The therapeutic efficacy and side-effects of two preparations of levodopa with extracerebral decarboxylase inhibitors have been compared in 19 patients with idiopathic parkinsonism in a blind randomised crossover trial. The mean daily dose of levodopa was 658 +/- 64 mg/day (mean +/- S.E.M.) when given together with carbidopa 66 mg/day and 605 +/- 59 mg/day(More)
Seventeen polymorphic microsatellite DNA markers were isolated from the loggerhead shrike (Lanius ludovicianus) using individuals from two geographically distinct populations (Ontario and mainland California). The number of alleles per locus ranged from 6 to 20 and expected heterozygosity varied from 0.639 to 0.902. All loci were heterozygous and private(More)
Comment Fraser et all in their original description of legionnaires' disease referred to three patients out of 182 with a WCC less than 2.0 x 109/1, two of whom died. Two other patients had WCCs of less than 6 0 x 109/1. During his acute illness our patient had pancytopenia with bone marrow depression. We can only speculate on the part played by(More)
The addition of bromocriptine, given in divided doses up to 30 mg per day, to conventional anti-Parkinsonism therapy has been studied in a double-blind placebo controlled clinical trial in 11 patients with Parkinsonism with the "on-off" syndrome. Four patients withdrew because of side effects. Of the seven remaining, three had clinical benefit from(More)
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