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1. The disposition and metabolic fate of ropinirole, a novel compound indicated for the symptomatic treatment of Parkinson's disease, was studied in the mouse, rat, cynomolgus monkey and man, following oral and intravenous administration of ropinirole hydrochloride. 2. In all species, nearly all of the p.o. administered dose (94%) was rapidly absorbed from(More)
We present deep Ka-band (ν ≈ 33 GHz) observations of the CMB made with the extended Very Small Array. This array produces a synthesized beam width (FWHM) of ∼ 11 arcmin and covers an ℓ-range of 300 to 1500. On these scales, foreground extragalactic sources can be a major source of contamination to the CMB anisotropy. This problem has been alleviated by(More)
The objectives of this study were to measure the pharmacokinetics of ropinirole at steady state when the drug is used as an adjunct to L-dopa and evaluate the long-term tolerability of ropinirole in this indication. Twenty-four patients who were taking L-dopa for Parkinson's disease and experiencing a lack of symptomatic control were recruited. Patients(More)
AIMS The aim of this single-blind study was to assess the effect of ropinirole, a novel treatment for Parkinson's disease, on the steady-state pharmacokinetics and safety of digoxin in 10 patients with Parkinson's disease. METHODS There were three parts to the study: digoxin once daily plus placebo three times daily for 1 week; digoxin once daily plus(More)
AIMS Ropinirole is a specific non-ergoline dopamine D2-receptor agonist with antiparkinsonian properties. The pharmacokinetic parameters of ropinirole taken in the fasted condition were compared with those when it was co-administered with food. METHODS This was an open, randomized, two sessions cross over study in 12 patients with Parkinson's disease,(More)
We have observed the cosmic microwave background in three regions of sky using the Very Small Array at 34 GHz. A total area of 101 square degrees has been imaged on angular scales of 3 • .6–0 • .4 (angular multipoles ℓ=150–900). Primordial anisotropies are detected at high significance in all three regions, and the signals seen in overlapping pointings(More)
The Very Small Array (VSA) is a synthesis telescope designed to image faint structures in the cosmic microwave background on degree and sub-degree angular scales. We have tested the operation of the VSA with a variety of blank-field and calibrator observations and cross-checked its calibration scale against independent measurements. We find that systematic(More)
Clover is a new instrument being built to detect the B-mode polarization of the CMB. It consists of three telescopes operating at 97, 150, and 220 GHz and will be sited in Chile at the Llano de Chajnantor. Each telescope assembly is scaled to give a constant beam size of 8 arcmin and feeds an array of between 320 and 512 finline-coupled TES bolometers. Here(More)
We estimate cosmological parameters using data obtained by the Very Small Array (VSA) in its extended configuration, in conjunction with a variety of other CMB data and external priors. Within the flat ΛCDM model, we find that the inclusion of high resolution data from the VSA modifies the limits on the cosmological parameters as compared to those suggested(More)