Angela A Liu
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Hydrogen Peroxide Induces Topoisomerase I-mediated DNA Damage and Cell Death*
- P. Daroui, S. Desai, T. Li, Angela A Liu, L. Liu
- Biology, Medicine
- Journal of Biological Chemistry
- 9 April 2004
Reactive oxygen species modify DNA, generating various DNA lesions including modified bases such as 8-oxoguanine (8-oxoG). These base-modified DNA lesions have been shown to trap DNA topoisomerase I… Expand
Cytotoxicity and TOP1-targeting activity of 8- and 9-amino derivatives of 5-butyl- and 5-(2-N,N-dimethylamino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-ones.
- L. Sharma, Yuan-chin Tsai, Angela A Liu, L. Liu, E. Lavoie
- Medicine, Chemistry
- European journal of medicinal chemistry
- 1 April 2009
Studies on substituted 5H-dibenzo[c,h][1,6]naphthyridin-6-ones and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones have demonstrated that hydrophilic substituents at the 2-position of an ethyl group at the… Expand