Angela A. Chang

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PURPOSE Due to its ability to disrupt transforming growth factor beta (TGF-β) signaling, halofuginone has been successfully used to treat various fibrotic disorders. Here we investigated the antifibrotic potential of halofuginone in human corneal fibroblasts. METHODS Human corneal fibroblasts were isolated from human donor corneas for in vitro(More)
Recent studies have revealed roles for immunoproteasome in regulating cell processes essential for maintaining homeostasis and in responding to stress and injury. The current study investigates how the absence of immunoproteasome affects the corneal epithelium under normal and stressed conditions by comparing corneas from wildtype (WT) mice and those(More)
PURPOSE Transforming growth factor beta-induced protein (TGFBIp) is a widely expressed extracellular matrix protein that plays roles in cell adhesion and migration, differentiation, apoptosis, bone morphogenesis, and carcinogenesis. Mutations of TGFBIp have been linked to stromal corneal dystrophies, a group of protein conformational diseases characterized(More)
143 may show a high T2 signal in the basal ganglia and caudate atrophy. Normal plasma lipid levels and lipoprotein electrophoresis help to distinguish this from abetalipoproteinaemia [4,6,8]. Proper evaluation of movement disorders in young people is necessary as there are important considerations regarding diagnosis, treatment and family counselling.(More)
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