Angel Pestaña

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BACKGROUND Retinoblastoma, a prototype of hereditary cancer, is the most common intraocular tumour in children and potential cause of blindness from therapeutic eye ablation, second tumours in germ line carrier's survivors, and even death when left untreated. The molecular scanning of RB1 in search of germ line mutations lead to the publication of more than(More)
BACKGROUND Epigenetic alterations and loss of heterozygosity are mechanisms of tumor suppressor gene inactivation. A new carcinogenic pathway, targeting the RAS effectors has recently been documented. RASSF1A, on 3p21.3, and NORE1A, on 1q32.1, are among the most important, representative RAS effectors. METHODS We screened the 3p21 locus for the loss of(More)
BACKGROUND RAD54L (OMIM 603615, Locus Link 8438) has been proposed as a candidate oncosupressor in tumours bearing a non-random deletion of 1p32, such as breast or colon carcinomas, lymphomas and meningiomas. In a search for RAD54L mutations in 29 menigiomas with allelic deletions in 1p, the only genetic change observed was a silent C/T transition at(More)
The aim of this study is to establish an estimation of the global genomic alteration in neuroblastic tumors (ganglioneuromas, ganglioneuroblastomas and neuroblastomas) and correlate them with different clinical parameters (age, sex, diagnosis, Shimada index, proliferation index, tumor location, and 1p and v-myc avian myelocitomatosis viral-related (MYCN)(More)
  • Fernand Pelloutier, Victor Griffuelhes, Emile Pouget, France, Armando Borghi, Alceste Deambris +18 others
  • 2011
Introduction During the first two decades of the twentieth century, amidst an extraordinary international upsurge in strike action, the ideas of revolutionary syndicalism connected with and helped to produce mass workers' movements in a number of different countries across the world. An increasing number of syndicalist unions, committed to destroying(More)