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In this research, we propose a highly predictable, low overhead, and, yet, dynamic, memory-allocation strategy for embedded systems with scratch pad memory. A <i>scratch pad</i> is a fast compiler-managed SRAM memory that replaces the hardware-managed cache. It is motivated by its better real-time guarantees versus cache and by its significantly lower(More)
— This paper presents the first-ever compile-time method for allocating a portion of the heap data to scratch-pad memory. A scratch-pad is a fast directly addressed compiler-managed SRAM memory that replaces the hardware-managed cache. It is motivated by its better real-time guarantees vs cache and by its significantly lower overheads in access time, energy(More)
Fungal dimorphism is the capacity of certain species of fungi to grow in the form of budding yeasts or mycelium depending on the environmental conditions. This characteristic is a complex phenomenon that involves modifications of the molecular machinery in response to different environmental signals. Through the use of microarrays, in this work we(More)
This paper presents the first memory allocation scheme for embedded systems having scratch-pad memory whose size is unknown at compile time. A scratch-pad memory (SPM) is a fast compiler-managed SRAM that replaces the hardware-managed cache. Its uses are motivated by its better real-time guarantees as compared to cache and by its significantly lower(More)
Immunoscreening of a Candida albicans expression library resulted in the isolation of a novel gene encoding a 32.9-kDa polypeptide (288 amino acids), with 27.7% homology to the product of Saccharomyces cerevisiae YGR106c, a putative vacuolar protein. Heterozygous mutants in this gene displayed an altered budding growth pattern, characterized by the(More)
This paper presents the first scratch-pad memory allocation scheme that requires no compiler support for interpreted-language based applications. A scratch-pad memory(SPM) is a fast compiler-managed SRAM that replaces the hardware-managed cache. Its uses are motivated by its better realtime guarantees as compared to cache and by its significantly lower(More)
Cell wall mannoproteins are largely responsible for the adhesive properties and immunomodulation ability of the fungal pathogen Candida albicans. The outer chain extension of yeast mannoproteins occurs in the lumen of the Golgi apparatus. GDP-mannose must first be transported from the cytosol into the Golgi lumen, where mannose is transferred to mannans.(More)
Fungal dimorphism is important for survival in different environments and has been related to virulence. The ascomycete Yarrowia lipolytica can grow as yeast, pseudomycelial or mycelial forms. We have used a Y. lipolytica parental strain and a Deltahoy1 mutant, which is unable to form hypha, to set up a model for dimorphism and to characterize in more depth(More)
Diclofenac sodium is a non-steroidal anti-inflammatory drug that inhibits filamentation in Candida albicans. Here we examined the effect of diclofenac sodium on hypha formation in C. albicans. The C. albicans cells were treated with various concentrations of diclofenac sodium (50, 100, 200 and 500microg/ml) and incubated at 37 degrees C for 2h. The(More)
The Efg1p regulator protein permits hyphal morphogenesis in the human fungal pathogen Candida albicans. We have identified the major promoter of the EFG1 gene as a direct target of Efg1p, resulting in negative autoregulation of EFG1. Enhanced activity of protein kinase A (PKA) isoforms Tpk1p and Tpk2p or exogenous overexpression of EFG1 led to(More)