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Total synthesis of platensimycin.
Total synthesis of (-)-fusarisetin A and reassignment of the absolute configuration of its natural counterpart.
The first total synthesis of (-)-fusarisetin A, the enantiomer of naturally occurring acinar morphogenesis inhibitor (+)-fusarisetin A, was accomplished in 13 steps, leading to the reassignment ofExpand
Total synthesis of indotertine A and drimentines A, F, and G.
The first total synthesis of drimentines A, G, and F (1–3) is reported, exploiting a photocatalyzed radical conjugate addition to address the problem of the C10b–C12 bond formation. Expand
Triflic acid promoted synthesis of polycyclic aromatic compounds
The triflic acid (CF3SO3H) promoted cyclizations of 2-styrylbiaryls are found to be useful for the synthesis of polycyclic aromatic compounds, including functionalized derivatives of polycyclicExpand
Total synthesis of the Daphniphyllum alkaloid daphenylline.
This work describes the first total synthesis of daphenylline, a structurally unique member among the predominately aliphatic Daphniphyllum alkaloids, and contains a tetrasubstituted arene moiety mounted on a sterically compact hexacyclic scaffold. Expand
Total synthesis of rubriflordilactone A.
The first and asymmetric total synthesis of rubriflordilactone A, a bisnortriterpenoid isolated from Schisandra rubriflora, has been accomplished in a convergent manner. Two enantioenriched fragmentsExpand
Total Synthesis of Longeracinphyllin A.
The first and asymmetric total synthesis of longeracinphyllin A, a hexacyclic Daphniphyllum alkaloid, has been accomplished and the cyclopentenone motif was assembled by using intramolecular Horner-Wadsworth olefination. Expand
Total Syntheses of Daphenylline, Daphnipaxianine A, and Himalenine D.
Inspired by the proposed biosynthetic relationship between 1 and another calyciphylline A type alkaloid, a ring-expansion/aromatization/aldol cascade and versatile triketone intermediate were developed to construct the tetrasubstituted benzene moiety of 1. Expand
Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexity.
The biological data obtained reveal that, while the substituted benzoic acid domain of platensimycin is a highly conserved structural motif within the active compounds with strict functional group requirements, the cage domain of the molecule can tolerate considerable structural modifications without losing biological action. Expand
Total Synthesis of Hybridaphniphylline B.
This is the first total synthesis of 1 featuring a late-stage intermolecular Diels-Alder reaction of a fully elaborated cyclopentadiene and asperuloside tetraacetate and the diene was prepared on the basis of a scalable route to daphnilongeranin B. Expand