Anette Brüggemann

Learn More
We have investigated the possible implication of the cell cycle-regulated K(+) channel ether à go-go (EAG) in cell proliferation and transformation. We show that transfection of EAG into mammalian cells confers a transformed phenotype. In addition, human EAG mRNA is detected in several somatic cancer cell lines, despite being preferentially expressed in(More)
We have cloned a mammalian (rat) homologue of Drosophila ether á go-go (eag) cDNA, which encodes a distinct type of voltage activated potassium (K) channel. The derived Drosophila and rat eag polypeptides share > 670 amino acids, with a sequence identity of 61%, exhibiting a high degree of similarity at the N-terminus, the hydrophobic core including the(More)
The Drosophila ether-à-go-go (eag) mutant is responsible for altered potassium currents in excitable tissue. These mutants exhibit spontaneous, repetitive firing of action potentials in the motor axons of larval neuromuscular junctions. The eag gene encodes a polypeptide that shares sequence similarities with several different ionic channel proteins,(More)
The cell cycle is the crucial process that leads to mitosis in all cell types. The dramatic redirectioning of many cellular processes during the cycle is known to involve ion channels, either changing their level of expression or their voltage dependence, as in the case of inward rectifiers. Here we describe the specific inhibition of heterologously(More)
Beschrieben wird der ungewöhnliche klinische Befund eines schnell wachsenden, exophytischen, unpigmentierten Bindehauttumors einer 57-jährigen Frau, der mittels histopathologischer Untersuchungen als malignes Melanom der Bindehaut diagnostiziert wurde. Die unterschiedlichen Phänotypen und das äußerst seltene Auftreten dieser Erkrankung erschweren eine(More)
Therapeutisch kommt bei ihnen auger einer strengen S~uberung der Umgebung und der dringenden Warnung an den Patienten, jede Art yon Manipulation am Geh6rgang zu vermeiden, nichts anderes in Betracht. Bei den geringftigigen Beschwerden, wie sie yon unseren beiden Patienten geiiugert werden, k6nnte man sich wohl kaum dazu entschlieBen, die yon P a y e r(More)
After animal experiments suggested there was an interaction between growth hormone and bone healing, our aim in this paper was to ascertain whether there were any changes or possible interaction between the serum level of growth hormone, somatomedin C and alkaline phosphatase while a fractured bone was healing. To this end, the serum concentrations of(More)
Kidney protection in dogs was performed with the HTK solution, renal transplantation following after 48 h of cold ischemia. All kidney transplants developed primary urine excretion with postoperative creatinine increase of under 8 mg% on average and a rapid creatinine decrease from the 4th postoperative day on. After 2 weeks, the initial creatinine value(More)
Eine 24-jährige Patientin stellte sich notfallmäßig mit einer seit 1 Tag bestehenden Sehverschlechterung und Verschwommensehen am rechten Auge vor. Anamnestisch ließen sich keine ophthalmologischen Erkrankungen feststellen. In der Familie ist eine Glaukomerkrankung bekannt. Die internistische Evaluation umfasst eine Adipositas permagna sowie drastisch(More)
  • 1