Anet H A Klaassens

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OBJECTIVE To evaluate histological and immunohistochemical parameters of short-term (21 days) tibolone, estrogen-only, and estrogen+progestagen treatment in the human postmenopausal endometrium. DESIGN An observational, open, nonrandomized, controlled study. SETTING Three collaborating centers: Amphia Hospital in Breda, Albert Schweitzer Hospital in(More)
Tibolone, a tissue-selective compound with a combination of estrogenic, progestagenic, and androgenic properties, is used as an alternative for estrogen or estrogen plus progesterone hormone therapy for the treatment of symptoms associated with menopause and osteoporosis. The current study compares the endometrial gene expression profiles after short-term(More)
BACKGROUND Combined hormone treatments in post-menopausal women have different clinical responses on uterus and vagina; therefore, we investigated differences in steroid signalling between various hormone therapies in these tissues. METHODS A total of 30 post-menopausal women scheduled for hysterectomy were distributed into four subgroups: control-group(More)
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