Ane Caroline Gaspardi

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BACKGROUND The RHD gene is highly polymorphic, which results in a large number of RhD variant phenotypes. Discrepancies in RhD typing are still a problem in blood banks and increase the risk of alloimmunization. In this study, the RhD typing strategy at a blood bank in Brazil was evaluated. METHODS One-hundred and fifty-two samples typed as RhD negative(More)
BACKGROUND As a consequence of the homology and opposite orientation of RHD and RHCE, numerous gene rearrangements have occurred in Africans and resulted in altered RH alleles that predict partial antigens, contributing to the high rate of Rh alloimmunisation among patients with sickle cell disease (SCD). In this study, we characterised variant RH alleles(More)
BACKGROUND Alloimmunisation is a major complication in patients with sickle cell disease (SCD) receiving red blood cell (RBC) transfusions and despite provision of Rh phenotyped RBC units, Rh antibodies still occur. These antibodies in patients positive for the corresponding Rh antigen are considered autoantibodies in many cases but variant RH alleles found(More)
V ariant D phenotypes are evidenced as serologic discrepancies with different anti-D reagents or reduced intensity of the hemagglutination reaction or if anti-D alloantibodies are detected in D1 individuals. The serologic assignment of the D status may be hindered in such situations. Molecular analysis allows the characterization of the allele involved in(More)
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