Andy Wijaya

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Combination therapy, or the use of multiple drugs, has been proven to be effective for complex diseases, but the differences in chemical properties and pharmacokinetics can be challenging in terms of the loading, delivering, and releasing multiple drugs. Here we demonstrate that we can load and selectively release two different DNA oligonucleotides from two(More)
Customizable ligand exchange of gold nanorods (NRs) is described. NRs are synthesized with the cationic surfactant cetyltrimethylammonium bromide (CTAB) which is exchanged with thiolated ligands that enable suspension in buffer. Exchange is achieved by a two phase extraction. First, CTAB is removed from the NR-CTAB by extracting the NRs into an organic(More)
Gold nanorods (GNRs) stabilized with cetyltrimethylammonium bromide (CTAB) and GNR functionalized via a ligand exchange method with either thiolated polyethylene glycol (PEG(5000)) or mercaptohexadecanoic acid (MHDA) were investigated for their stability in biological media and subsequent toxicological effects to HaCaT cells. GNR-PEG and GNR-MHDA exhibited(More)
We report a morphological study of the encapsulation of 12-nm Fe3O4 nanoparticles (NPs) in large unilamellar vesicles of dipalmitoylphosphatidylcholine (DPPC). Preparation was done by reverse-phase evaporation. Phase behavior of the NP-lipid system was studied so that the loading of NPs in vesicles could be maximized. Increasing NP concentration(More)
Acknowledgements First and foremost, I would like to thank my advisor, Professor Mohammad Movassaghi for his advice, support, and guidance over the last six years. I am grateful to him for giving me the opportunity to work on challenging and rewarding projects in my graduate study. I would also like to thank members of my thesis committee, Professor Tim(More)
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