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The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation
TLDR
Differences in binding to viral peptide antigens by HLA may be the major factors underlying genetic differences between HIV controllers and progressors, and genome-wide association results implicate the nature of the HLA–viral peptide interaction as the major factor modulating durable control of HIV infection.
Propionibacterium acnes Host Inflammatory Response During Periprosthetic Infection Is Joint Specific
TLDR
Inflammatory markers were significantly higher in the knee and hip groups compared to the hip and shoulder groups, and long hold anaerobic cultures up to 14 days are necessary to accurately identify this organism.
Clinical Analysis of Propionibacterium acnes Infection After Total Knee Arthroplasty.
TLDR
P acnes TKA infections are associated with more acute inflammatory symptoms than typically appreciated, and long hold anaerobic cultures up to 14 days are necessary to accurately identify this organism as the causative agent of TKA periprosthetic infection.
The Role of Long-Term Antibiotic Suppression in the Management of Peri-Prosthetic Joint Infections Treated With Debridement, Antibiotics, and Implant Retention: A Systematic Review.
TLDR
There is still only low-quality evidence regarding the therapeutic effect of DAIR combined with SAT, which is not enough to draw definitive conclusions, and high-quality prospective studies are needed to better understand SAT's efficacy and safety in a controlled fashion.
Cost-Effectiveness of Staphylococcus aureus Decolonization Strategies in High-Risk Total Joint Arthroplasty Patients.
TLDR
S aureus decolonization may be cost-effective for reducing prosthetic joint infections in high-risk patients and for cost containment in a bundled payment system.
Periprosthetic Joint Infection in Patients with Inflammatory Joint Disease: a Review of Risk Factors and Current Approaches to Diagnosis and Management
TLDR
It remains unclear whether using anti-tumor necrosis factor medications perioperatively increases the risk of surgical site infections and the evidence suggests that two-stage revision or resection arthroplasty is more likely to eradicate infection, particularly when MRSA is the pathogen.
Chronic Osteomyelitis of the tibia and ankle treated with Limb Salvage Reconstruction
TLDR
Limb salvage is a reliable and successful treatment for patients with chronic osteomyelitis and infected non-unions of the lower extremities and diabetic neuropathy is a risk factor that impedes success.
Globicatella sanguinis Osteomyelitis and Bacteremia: Review of an Emerging Human Pathogen with an Expanding Spectrum of Disease
TLDR
Globicatella sanguinis, an uncommon pathogen with elevated minimum inhibitory concentrations to third-generation cephalosporins, is difficult to identify by phenotypic methods and typically causes infections in females at the extremes of age.
Are Intraoperative Cultures Necessary If the Aspiration Culture Is Positive? A Concordance Study in Periprosthetic Joint Infection.
TLDR
Aspiration culture has favorable sensitivity and specificity when compared to tissue culture for identifying the majority of PJI organisms, but Clinicians should strongly consider collecting multiple tissue cultures to maximize the chance of identifying an underlying polymicrobial PJI.
Success rates, characteristics, and costs of articulating antibiotic spacers for total knee periprosthetic joint infection.
TLDR
There was no statistically significant difference in the success rates between the antibiotic spacer types, and the surgeon's own intraoperatively created mold group had the least overall associated cost.
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