Andy L. Johnson

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Dynamic reprogramming of metabolism is essential for T cell effector function and memory formation. However, the regulation of metabolism in exhausted CD8(+) T (Tex) cells is poorly understood. We found that during the first week of chronic lymphocytic choriomeningitis virus (LCMV) infection, before severe dysfunction develops, virus-specific CD8(+) T cells(More)
In this paper, we discuss three-stage models that control for exogenous, non-discretionary inputs in data envelopment analysis. In a recent article in this journal, Monte Carlo analysis was employed to compare and contrast alternative DEA models that measure efficiency in the presence of exogenous variables. The methodology for comparison was flawed,(More)
High-affinity class-switched Abs and memory B cells are products of the germinal center (GC). The CD4+ T cell help required for the development and maintenance of the GC is delivered by follicular Th cells (T(FH)), a CD4+ Th cell subset characterized by expression of Bcl-6 and secretion of IL-21. The cellular interactions that mediate differentiation of TFH(More)
Effective benchmarking requires standards for measuring performance across a broad range of organizations. Industry benchmarking measures the relative performance levels of similar operations, but gathering sufficient data to robustly characterize best performance is the primary hurdle to more widespread implementation. This paper describes the development(More)
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