Andy Jennings

Ruhi Kamran1
Emiko Koumura1
Hikaru Ueno1
1Ruhi Kamran
1Emiko Koumura
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Molecular shape and electrostatic distribution play a crucial role in enzyme and receptor recognition and contribute extensively to binding affinity. Molecular similarity and bioisosterism are much-discussed topics in medicinal chemistry. Many molecular representations and similarity metrics are available to help drug discovery, and activities such as(More)
  • Charles E. Grimshaw, Andy Jennings, Ruhi Kamran, Hikaru Ueno, Nobuhiro Nishigaki, Takuo Kosaka +6 others
  • 2016
Trelagliptin (SYR-472), a novel dipeptidyl peptidase-4 inhibitor, shows sustained efficacy by once-weekly dosing in type 2 diabetes patients. In this study, we characterized in vitro properties of trelagliptin, which exhibited approximately 4- and 12-fold more potent inhibition against human dipeptidyl peptidase-4 than alogliptin and sitagliptin,(More)
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