Andy Futreal

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Sensitivity to Her2-directed therapies is complex and involves expression not only of Her2 but also of other epidermal growth factor receptor (EGFR) family members, their ligands, and molecules that influence pathway activity, such as insulin-like growth factor-1 receptor, PTEN, and p27. The EGFR experience has taught us that responses can easily be diluted(More)
Men who inherit a mutation in the BRCA2 gene carry a 6% risk of developing breast cancer by the age of 70. The proportion of male breast cancers attributable to BRCA mutations has not yet been determined with accuracy. We studied a series of 14 male breast cancer patients, unselected for family history or ethnicity, who were treated at a single regional(More)
Cyclin-dependent kinase 2 (cdk2) is a central regulator of the mammalian cell cycle. Here we describe the properties of a mutant form of cdk2 identified during large-scale sequencing of protein kinases from cancerous tissue. The mutation substituted a leucine for a proline in the PSTAIRE helix, the central motif in the interaction of the cdk with its(More)
  • Andy Futreal
  • Annals of oncology : official journal of the…
  • 2014
A. Futreal MD Anderson Cancer Center, Houston, TX, USA Insight into the somatic genetics of clear cell renal cell carcinoma (ccRCC) has seen considerable advance in the past few years. Leveraging DNA sequencing approaches we have now begun to elaborate the picture of ccRCC, expanding from that dominated by VHL mutation into a more nuanced and complex view(More)
Advances in sequencing technology have led to an unprecedented opportunity to characterize the genomes of human cancers. Our work has been focused on characterizing intraand intertumoral heterogeneity in several tumor types. Work on breast cancer has revealed substantial complexity of operative cancer genes, with marked diversity between cancers revealed by(More)
O1 The metabolomics approach to autism: identification of biomarkers for early detection of autism spectrum disorder A. K. Srivastava, Y. Wang, R. Huang, C. Skinner, T. Thompson, L. Pollard, T. Wood, F. Luo, R. Stevenson O2 Phenome-wide association study for smoking- and drinking-associated genes in 26,394 American women with African, Asian, European, and(More)
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