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BACKGROUND Unlicensed medications are used all the time in the management of diseases in childhood. Tolvaptan (Jinarc®) is a vasopressin V2-receptor antagonist licensed for use to slow the progression of cyst development and renal insufficiency of ADPKD in adults with CKD stage 1 to 3 with evidence of rapidly progressing disease. Studies of animal models(More)
OBJECTIVE Previous research suggests that anorexic behaviour may be an attempt to introduce control into a chaotic environment, and that the need for stability and meaning in life is an important factor in the development of psychopathologies. The phenomenon of 'existential anxiety' is a characteristic reaction to a lack of meaning in the life of an(More)
Technology mapping is an important step in the FPGA CAD flow in which a network of simple gates is converted into a network of logic blocks. We consider enhancements to a traditional LUT-based mapping algorithm for an FPGA comprised of logic blocks which implement only a subset of functions of up to k variables--specifically, the logic block is a partial(More)
  • A Fox
  • 1984
This article details the changes in total income and the composition of its sources that occur upon initial receipt of Social Security benefits, and in the first 4 years thereafter. The study shows that, for many persons, "retirement" is a gradual process rather than an immediate cessation of all paid work. About half the persons entering the rolls continue(More)
AIMS To assess the rates of violence in nursery rhymes compared to pre-watershed television viewing. METHODS Data regarding television viewing habits, and the amount of violence on British television, were obtained from Ofcom. A compilation of nursery rhymes was examined for episodes of violence by three of the researchers. Each nursery rhyme was analysed(More)
Due to poor correlations between pre- and post-placement timing analysis, many post-placement optimization strategies have been proposed for the FPGA CAD flow to improve circuit performance. Typically, these methods depend on logic duplication or decomposition methods combine together with incremental placement. Circuit rewriting has proven to be a useful(More)
AIMS The aim of the study was to develop a list of hospital based paediatric prescribing indicators that can be used to assess the impact of electronic prescribing or clinical decision support tools on paediatric prescribing errors. METHODS Two rounds of an electronic consensus method (eDelphi) were carried out with 21 expert panellists from the UK.(More)
  • A Fox
  • 1982
This article describes and reports on the degree to which Social Security and private pensions replaced preretirement earnings for a sample of individuals retiring in the early 1970's. Although simple in concept, replacement rates can be defined in many different ways. Because no one definition is best for all purposes, several are considered, and the(More)
Recent research has suggested that normal adolescent processes are important in understanding psychosis, and that young adult individuals with psychosis are often struggling to develop an individual and autonomous self (the "fundamental task" of adolescence). The current paper explores the utility of considering normative adolescent developmental processes(More)