Andrzej Werynski

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Standard peritoneal ultrafiltration characteristics in 18 patients undergoing continuous ambulatory peritoneal dialysis (CAPD) were investigated in a total of 21 single dwell studies of 6 h duration with 2 L of 3.86% glucose dialysis fluid. Intraperitoneal dialysate volumes were determined using radioiodinated serum albumin (RISA). Calculations were based(More)
BACKGROUND Fluid and sodium removal is often inadequate in peritoneal dialysis patients with high peritoneal solute transport rate, especially when residual renal function is declining. METHOD We studied the effects of using simultaneous crystalloid (glucose) and colloid (icodextrin) osmotic agents on the peritoneal transport of fluid, sodium, and other(More)
Mass transport coefficients usually are assumed to be constant during single 6 hr exchanges of dialysis fluid in continuous ambulatory peritoneal dialysis (CAPD). To check this assumption, the authors estimated diffusive mass transport coefficients, KBD, for five low molecular weight solutes in 34 dwell studies with glucose 3.86% (20 studies), glucose 2.27%(More)
BACKGROUND Diffusive transport between blood and dialysate during peritoneal dialysis is evaluated in clinical and experimental studies by the diffusive mass transport coefficient, KBD. This global parameter depends on the local diffusive characteristics of the blood capillary wall (permeability) and the tissue, as well as on the density and distribution of(More)
BACKGROUND Controlling extracellular volume and plasma sodium concentration are two crucial objectives of dialysis therapy, as inadequate sodium and fluid removal by dialysis may result in extracellular volume overload, hypertension, and increased cardiovascular morbidity and mortality in end-stage renal disease patients. A new concept to enhance sodium and(More)
Peritoneal fluid transport can be predicted using different simplified formulas. To evaluate three such models, fluid transport was studied in 38 single six hour dwell studies using standard glucose 1.36% (n = 9), 2.27% (n = 9) and 3.86% (n = 20) dialysis fluids as well as amino acid 2.70% fluid (n = 8) in 33 patients on continuous ambulatory peritoneal(More)
During a 10 year period, 14 out of 227 patients (6.2%) undergoing continuous ambulatory peritoneal dialysis (CAPD) developed permanent loss of ultrafiltration capacity (UFC). The risk of UFC loss increased from 2.6% after one year to 30.9% after six years of treatment. A six hour, single dwell study with glucose 3.86% dialysis fluid was carried out in nine(More)
To quantitatively evaluate peritoneal sodium transport, the diffusive mass transport coefficient (KBD) and sieving coefficient (S), as well as the mass of sodium transported by diffusion (DM), by convection (CM) and by fluid absorption (AM) and the total sodium mass removed (RM) were calculated during a series of single dwell studies in CAPD patients. A(More)
To investigate the relationship between dialysate glucose concentration and peritoneal fluid and solute transport parameters, 41 six-hour single dwell studies with standard glucose-based dialysis fluids containing 1.36% (N = 9), 2.27% (N = 9) and 3.86% (N = 23) anhydrous glucose were carried out in 33 clinically-stable continuous ambulatory peritoneal(More)
The quantitative description of diffusive and convective mass transport of small solutes in peritoneal dialysis is dependent on accurate determination and appropriate expression of the concentration of investigated substances. For small solutes which easily equilibrate between dialysate and plasma the solute concentration in plasma should be expressed per(More)