Andrzej Wedrychowski

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Anti-CD3 antibodies of some IgG subclasses are very potent T lymphocyte mitogens in vitro and, seemingly contradictorily, very effective immunosuppressive agents in vivo. Using hamster anti-murine CD3 monoclonal antibody, 2C11, as a model, we have found that 2C11.IgG, or its F(ab')2 fragment, coupled to microbeads can provide short-term and vigorous(More)
When NovikofT hepatoma-bearing rats were given injections of a therapeutic dose of cM-diamminedichloroplatinum(II) (rÃ2-DDP) (7 mg/ kg), DNA-protein cross-links could be detected by using antisera to dehistonized chromatin, nuclear matrix, or Novikoff hepatoma i->(»skel etal preparation. The extent of cross-linking increased in time up to 24 h after the(More)
Protein-DNA interactions of the human myeloid cell nuclear differen tiation antigen (MNDA) were examined in vivo in proliferating HL-60 promyelocytic leukemia cells and following induction of differentiation by 1,25-dehydroxyvitamin I),. Intact cells were treated with the reversible cross-linking agent m-diamminedichloroplatinum(II) and the MNDA levels in(More)
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