Andrzej Wasilewski

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Genetic polymorphisms in DNA repair genes may induce individual variations in DNA repair capacity, which may in turn contribute to the risk of cancer developing. Homologous recombination repair (HRR) plays a critical role in maintaining chromosomal integrity and protecting against carcinogenic factors. The aim of the present study was to evaluate the(More)
Increased amounts of autologous immunoglobulin (Ig) G were found on older bovine erythrocytes employing 125I-labelled Protein A, 125I-labelled anti(bovine IgG) antibodies and hemolysis in the presence of anti(bovine IgG) antibodies + complement. In vitro, desialylation, proteolysis and action of an O2-. source but not glycosylation induced binding of(More)
The composition of membrane proteins was compared in erythrocyte fractions of different mean age by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate and crossed immunoelectrophoresis. An increase in the content of high-molecular-weight protein aggregates with cell aging was confirmed, and enhanced binding of some hemolysate(More)
BACKGROUND The opioid system in the gastrointestinal (GI) tract plays an important physiological role, but is also responsible for the side effect of opioid drugs, including troublesome constipation in chronic pain treatment. The aim of this study was to characterize and validate a new mouse model to study the effects of opioid agonists and antagonists in(More)
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