Andrzej Stelter

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BACKGROUND AND PURPOSE Gene transfer with recombinant viral vectors encoding vasodilator proteins may be useful in therapy of cerebral vasospasm after subarachnoid hemorrhage (SAH). Relaxations mediated by nitric oxide are impaired in cerebral arteries affected by SAH. The present study was designed to determine the effect of SAH on the efficiency of ex(More)
In vascular endothelial cells, tetrahydrobiopterin serves as an essential cofactor required for enzymatic activity of nitric oxide synthase. GTP cyclohydrolase I is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin. Previous studies have demonstrated that proinflammatory cytokines stimulate production of tetrahydrobiopterin in endothelial(More)
Three distinct genes encode the three isoforms of the inositol triphosphate (IP3) receptor (type I, II and III) expressed in brain. Coupling domain of neuronal type I receptor contains a 117 nucleotide insert located between two cyclic AMP-dependent protein kinase (PKA) phosphorylation consensus sequences. By contrast, in nonneuronal tissues this insert is(More)
Triiodothyronine (T3) induces the transcription of the human chorionic somatomammotropin (hCS) promoter transfected into rat pituitary (GC) cells, but does not stimulate the homologous human growth hormone (hGH) promoter. As demonstrated by forward and reverse mutagenesis, this differential T3 responsiveness is due to subtle structural differences in a T3(More)