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- Ion Petre, Andrzej Mizera, +6 authors Ralph-Johan Back
- Natural Computing
- 2010

The heat shock response is a primordial defense mechanism against cell stress and protein misfolding. It proceeds with the minimum number of mechanisms that any regulatory network must include, a stress-induced activation and a feedback regulation, and can thus be regarded as the archetype for a cellular regulatory process. We propose here a simple… (More)

- Norbert Dojer, Anna Gambin, Andrzej Mizera, Bartek Wilczynski, Jerzy Tiuryn
- BMC Bioinformatics
- 2005

A central goal of molecular biology is to understand the regulatory mechanisms of gene transcription and protein synthesis. Because of their solid basis in statistics, allowing to deal with the stochastic aspects of gene expressions and noisy measurements in a natural way, Bayesian networks appear attractive in the field of inferring gene interactions… (More)

- Panuwat Trairatphisan, Andrzej Mizera, Jun Pang, Alexandru Adrian Tantar, Jochen Schneider, Thomas Sauter
- Cell Communication and Signaling
- 2013

Probabilistic Boolean network (PBN) modelling is a semi-quantitative approach widely used for the study of the topology and dynamic aspects of biological systems. The combined use of rule-based representation and probability makes PBN appealing for large-scale modelling of biological networks where degrees of uncertainty need to be considered. A… (More)

- Andrzej Mizera, Barbara Gambin
- Journal of theoretical biology
- 2010

The heat shock response (HSR) is a highly evolutionarily conserved defence mechanism allowing the cell to promptly react to elevated temperature conditions and other forms of stress. It has been subject to intense research for at least two main reasons. First, it is considered a promising candidate for deciphering the engineering principles underlying… (More)

- Panuwat Trairatphisan, Andrzej Mizera, Jun Pang, Alexandru Adrian Tantar, Thomas Sauter
- PloS one
- 2014

BACKGROUND
There exist several computational tools which allow for the optimisation and inference of biological networks using a Boolean formalism. Nevertheless, the results from such tools yield only limited quantitative insights into the complexity of biological systems because of the inherited qualitative nature of Boolean networks.
RESULTS
We… (More)

- Andrzej Mizera, Eugen Czeizler, Ion Petre
- Trans. Computational Systems Biology
- 2012

Model refinement is an important aspect of the model-building process. It can be described as a procedure which, starting from an abstract model of a system, performs a number of refinement steps in result of which a more detailed model is obtained. At the same time, in order to be correct, the refinement mechanism has to be capable of preserving already… (More)

- Andrzej Mizera, Jun Pang, Qixia Yuan
- ATVA
- 2015

We present ASSA-PBN, a tool for approximate steady-state analysis of large probabilistic Boolean networks (PBNs). ASSA-PBN contains a constructor, a simulator, and an analyser which can approximately compute the steadystate probabilities of PBNs. For large PBNs, such approximate analysis is the only viable way to study their long-run behaviours. Experiments… (More)

- Andrzej Mizera, Jun Pang, Qixia Yuan
- ArXiv
- 2015

Probabilistic Boolean networks (PBNs) is a well-established computational framework for modelling biological systems. The steady-state dynamics of PBNs is of crucial importance in the study of such systems. However, for large PBNs, which often arise in systems biology, obtaining the steady-state distribution poses a significant challenge. In fact,… (More)

- Ion Petre, Andrzej Mizera, Ralph-Johan Back
- CiE
- 2009

Computational biomodelers adopt either of the following approaches: build rich, as complete as possible models in an effort to obtain very realistic models, or on the contrary, build as simple as possible models focusing only on the core aspects of the process, in an effort to obtain a model that is easier to analyze, fit, and validate. When the latter… (More)

- Xihui Chen, Andrzej Mizera, Jun Pang
- 2015 IEEE Conference on Communications and…
- 2015

The exposure of location information in location-based services (LBS) raises users' privacy concerns. Recent research reveals that in LBSs users concern more about the activities that they have performed than the places that they have visited. In this paper, we propose a new attack with which the adversary can accurately infer users' activities. Compared to… (More)