Mutations at the natural resistance–associated macrophage protein 1 (Nramp1) locus cause susceptibility to infection with antigenically unrelated intracellular pathogens. Nramp1 codes for an integral membrane protein expressed in the lysosomal compartment of macrophages, and is recruited to the membrane of phagosomes soon after the completion of… (More)
If controversies were to arise, there would be no more need of disputation between two philosophers than between two accountants. For it would suffice to take their pencils in their hands, and say to each other: 'Let us calculate'. – Gottfried Wilhelm Leibniz, Dissertio de Arte Combinatoria (Leipzig, 1666). ... Languages are the best mirror of the human… (More)
" The problem of understanding of intelligence is said to be the greatest problem in science today and " the " problem for this century – as deciphering the genetic code was for the second half of the latest one. Arguably, the problem of learning represents a gateway to understanding intelligence in brains and machines, to discovering how the human brain… (More)
We discuss how to support commanders at the fire ground. We present a risk management framework for modelling the fire phenomena and for communicating with firefighters. We claim that appropriate derivation, selection and representation of information is the crucial aspect of decision support, as it may improve the commander's perception.
Ask not what mathematics can do for biology; ask rather what biology can do for mathematics! – Stan Ulam Abstract. We discus the Wisdom Granular Computing (WGC) as a basic methodology in Wisdom Technology (WisTech). By wisdom, we understand an adaptive ability to make judgements correctly to a satisfactory degree (in particular, correct decisions) having in… (More)
Developing methods for approximation of compound concepts expressing the result of perception belongs to the main challenges of Perception Based Computing (PBC) . The perceived concepts are expressed in natural language. We discuss the rough-granular approach to approximation of such concepts from sensory data and domain knowledge. This additional… (More)
66. Consider for example the proceedings that we call " games " ... we see complicated network of similarities overlapping and criss-crossing: sometimes overall similarities, sometimes similarities of detail. 67. I can think of no better expression to characterize these similarities than " family resemblances " ; for the various resemblances between members… (More)
As far as the laws of mathematics refer to reality, they are not certain; and as far as they are certain, they do not refer to reality. – Albert Einstein () Constructing the physical part of the theory and unifying it with the mathematical part should be considered as one of the main goals of statistical learning theory – Vladimir Vapnik (, Epilogue:… (More)