Andriy Derkach

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Mitochondria are the main source of energy for neurons and have a role in many vital neuronal functions. Mitochondrial dysfunction has been described in schizophrenia, and antipsychotics such as clozapine and olanzapine have been associated with differences in gene expression in mitochondria. We investigated the hypothesis that nuclear-encoded mitochondrial(More)
MOTIVATION Sufficiently powered case-control studies with next-generation sequence (NGS) data remain prohibitively expensive for many investigators. If feasible, a more efficient strategy would be to include publicly available sequenced controls. However, these studies can be confounded by differences in sequencing platform; alignment, single nucleotide(More)
Many association tests have been proposed for rare variants, but the choice of a powerful test is uncertain when there is limited information on the underlying genetic model. Proposed methods use either linear statistics, which are powerful when most variants are causal and have the same direction of effect, or quadratic statistics, which are more powerful(More)
Grouping variants based on gene mapping can augment the power of rare variant association tests. Weighting or sorting variants based on their expected functional impact can provide additional benefit. We defined groups of prioritized variants based on systematic annotation of Genetic Analysis Workshop 18 (GAW18) single-nucleotide variants; we focused on(More)
The focus of our work is to evaluate several recently developed pooled association tests for rare variants and assess the impact of different gene annotation methods and binning strategies on the analyses of rare variants under Genetic Analysis Workshop 18 real and simulated data settings. We considered the sample of 103 unrelated individuals with sequence(More)
Pleiotropy, which occurs when a single genetic factor influences multiple phenotypes, is present in many genetic studies of complex human traits. Longitudinal family data, such as the Genetic Analysis Workshop 18 data, combine the features of longitudinal studies in individuals and cross-sectional studies in families, thus providing richer information about(More)
In a study of the flavonoids of Stachys inflata Benth. and St_..:.. a theroca lyx C. Koch., we have isola ted a flavonoid glycoside with mp 220-224°C, [ o~]2i~-60° (c 0.1; ethanol), giving on hydro lys i s with 5% sulfuric acid an aglycone CleHt20 ~, mp 340-343°C (dec.rap.) , and the two sugars D-mannose and D-glucose . F r o m i ts qualitative reac t ions(More)
In continuing investigations ofthe flavonoidsof this plant wehave isolated the total substances, which could not be separated by chromatography on paper in various systems. To establish the nature of the aglycones we hydrolyzed the combined glycosides with 5% sulfuric acid. The aglycones that deposited were separated on a column of polyamide sorbent (ratio(More)
From the epigeal part ofStachys spectabilis we have isolated three flavonoids: the known stachyflaside and isostachyflaside, and the new spectabiflaside (I). On the basis of chemical transformations and an analysis of spectral characteristics, for (I) we propose the structure of 4′,5,8-trihydroxy-7-[0-β-D-mannopyranosyl-(1 →(More)
A preliminary chromatographic analysis of the fruit, bark, and leaves of Sargent cranberry bush (Viburnum sargenu) Kohene showed the presence of cinnamic acid derivatives in the organs investigated. To isolate the phenolcarboxylic acids from the fruit of a far-eastern species of Viburnum, a weighed sample of the airdry comminuted raw material was extracted(More)