Andriy Derkach

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MOTIVATION Sufficiently powered case-control studies with next-generation sequence (NGS) data remain prohibitively expensive for many investigators. If feasible, a more efficient strategy would be to include publicly available sequenced controls. However, these studies can be confounded by differences in sequencing platform; alignment, single nucleotide(More)
Mitochondria are the main source of energy for neurons and have a role in many vital neuronal functions. Mitochondrial dysfunction has been described in schizophrenia, and antipsychotics such as clozapine and olanzapine have been associated with differences in gene expression in mitochondria. We investigated the hypothesis that nuclear-encoded mitochondrial(More)
Many association tests have been proposed for rare variants, but the choice of a powerful test is uncertain when there is limited information on the underlying genetic model. Proposed methods use either linear statistics, which are powerful when most variants are causal and have the same direction of effect, or quadratic statistics, which are more powerful(More)
By column chromatography on polyamide sorbent, the inflorescences of pot marigold calendula have yielded eight substances of flavonoid nature: two aglycons — quercetin (C15H10O7, mp 309–311°C) and isorhamnetin (C16H12O7, mp 314–316°C); six glycosides, of which three have been identified as isoquercetin (C21H20O12, [α] D 20 −36° in methanol, mp 218–220°C),(More)
Grouping variants based on gene mapping can augment the power of rare variant association tests. Weighting or sorting variants based on their expected functional impact can provide additional benefit. We defined groups of prioritized variants based on systematic annotation of Genetic Analysis Workshop 18 (GAW18) single-nucleotide variants; we focused on(More)
The focus of our work is to evaluate several recently developed pooled association tests for rare variants and assess the impact of different gene annotation methods and binning strategies on the analyses of rare variants under Genetic Analysis Workshop 18 real and simulated data settings. We considered the sample of 103 unrelated individuals with sequence(More)
Pleiotropy, which occurs when a single genetic factor influences multiple phenotypes, is present in many genetic studies of complex human traits. Longitudinal family data, such as the Genetic Analysis Workshop 18 data, combine the features of longitudinal studies in individuals and cross-sectional studies in families, thus providing richer information about(More)
In a study of the flavonoids of Stachys inflata Benth. and St_..:.. a theroca lyx C. Koch., we have isola ted a flavonoid glycoside with mp 220-224°C, [ o~]2i~-60° (c 0.1; ethanol), giving on hydro lys i s with 5% sulfuric acid an aglycone CleHt20 ~, mp 340-343°C (dec.rap.) , and the two sugars D-mannose and D-glucose . F r o m i ts qualitative reac t ions(More)
Continuing an investigation of the phenolic compounds of the epigeal part of Artemisia jacutica Drob, A. sieversiana Wild., and A. absinthium L. [1], we have isolated the phenolic carboxylic acids from a 70% ethanolic extract. An ethyl acetate fraction obtained by a method described previously [1] was, after the elimination of the extractant, deposited on a(More)