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BACKGROUND Essential tremor (ET) and Parkinson's disease (PD) are considered distinct disorders. The aim of the study was to look for a link or any distinguishing features by transcranial sonography (TCS), together with the clinical examination findings in a group of patients with overlapping phenotype of ET and PD (ET-PD). METHODS A prospective(More)
BACKGROUND Hyperechogenicity of the substantia nigra (SN+), detected by transcranial sonography (TCS), was reported as a characteristic finding in Parkinson's disease (PD), with high diagnostic accuracy values, when compared mainly to healthy controls or essential tremor (ET) group. However, some data is accumulating that the SN + could be detected in other(More)
This paper presents a novel and rapid method developed for semi-automated segmentation of the mid-brain region in B-mode trans-cranial ultrasound (TCS) images. TCS is a relatively new neuroimaging tool having promising application in early diagnosis of Parkinson's disease. The quality of TCS images is much lower compared with the ultrasound images obtained(More)
Images captured during routine clinical transcranial sonography (TCS) examination are of a low resolution, so can be confusing for diagnostic evaluations. Manual segmentation of brain structures (areas of the midbrain and substantia nigra (SN)) that are of special interest cause inter-observer and intra-observer variability, thus restricting the reliability(More)
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