Andrey V Peresypkin

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PURPOSE Diffusion coefficients of various retinoids have not been measured previously. It is important to know the diffusion coefficients of the retinoids because this property might be rate-limiting in dark adaptation. Also, retinoid diffusion is important to explore given that rhodopsin regeneration is not impaired in IRBP knockout mice. METHODS(More)
Three anhydrous polymorphs, a monohydrate and a dihydrate of an active pharmaceutical ingredient, N-{[(5S)-3-(4-{6-[(1R,5S)-6-cyano-3-oxabicyclo[3.1.0]hex-6-yl]pyridin-3-yl}phenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide (Compound 1), have been crystallized and characterized. Slurry experiments and thermal data have been used to determine their relative(More)
We report the first case of a pharmaceutical cocrystal formed between an inorganic acid and an active pharmaceutical ingredient (API), which enabled us to develop a stable crystalline and bioavailable solid dosage form for pharmaceutical development where otherwise only unstable amorphous free form or salts could have been used.
PURPOSE This study was conducted to evaluate the aggregation properties of an amphiphilic drug. METHODS Aggregation of the drug was studied by various methods including phase-contrast and polarized microscopy, spectrophotometry, surface tensiometry, atomic force microscopy, and dynamic light scattering. Lymph-cannulated rats were used to assess fractions(More)
PURPOSE The purpose of this study was to evaluate the physical form of 2-tert-butyl-4-methoxy-phenol (BHA) following wet granulation onto common pharmaceutical excipients. METHODS A 13C label was incorporated into the methoxy group of BHA, the major isomer in synthetic butylated hydroxyanisole. Solutions of the labeled BHA were used to load the labeled(More)
This is a study of 10 asymmetric gemini surfactants that self-assemble into vesicles which, in turn, self-assemble into gels. The geminis have the following general structure: long-chain/phosphate/2-carbon spacer/quaternary nitrogen/short-chain. Dynamic light scattering and transmission electron microscopy (TEM) demonstrate that in dilute aqueous systems(More)
We report formation and characterization of the first pharmaceutically acceptable and stable molecular complex of a mono-HCl salt of Compound 1 with HCl. The novelty of this discovery is due to the fact that there is only one major basic site in the molecule. Thus this complex is reminiscent of other noncovalent crystalline forms including solvates,(More)
A method to detect and quantify a small amount crystalline material within a liquid solution of solubilized material is described. 19F CP-MAS ssNMR was investigated as a technique to detect low levels (0.2 mg/g) of crystalline sodium (2R)-7-{3-[2-chloro-4-(2,2,2-trifluoroethoxy)phenoxy]propoxy}-2-methyl-3,4-dihydro-2H-chromane-2-carboxylate (I) within a(More)
We report the formation of aqueous gels at low concentrations (less than 1 wt%) of an amphiphilic drug, a derivative of a chromane-2-carboxylic acid, at pH values 6.2-6.4. Formation of gels in the vicinity of the apparent pK(a) of the drug suggests that on the molecular level, the gels are composed of the aggregates of the ionized and protonated forms of(More)
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