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In order to assess the characteristics of its stromal cells and the distribution of extracellular matrix proteins, we investigated, immunohistochemically and ultrastructurally, term, first and second trimester human umbilical cords. A differential distribution pattern of the various cytoskeletal proteins of stromal cells and extracellular matrix proteins(More)
The aim was to determine whether the fetal vasculature of the human placenta adapts in a uniform manner to different forms of hypoxic stress. Stereological analyses were performed on the intermediate and terminal villi of placentae obtained from each of the following conditions; high altitude (up to 2800 m), maternal iron-deficiency anaemia and(More)
The localization of human carbonic anhydrase (CA) isoenzymes HCA I, HCA II, and rat CA II have been studied in human umbilical cord, chorion laeve including amnion and placenta from first and second trimester and also from term pregnancies. Detection techniques of immunofluorescence and immunoperoxidase were used in cryostat and paraffin sections. Both(More)
OBJECTIVE Our purpose was to determine whether the human placenta is able to adapt structurally to hypobaric hypoxia so as to increase its diffusing capacity. STUDY DESIGN Material from 10 normal term placentas collected at each of three altitudinal levels in Kirghizstan was analyzed stereologically. Data were compared by one-way analysis of variance. (More)
Distribution of collagen types I, III, IV, V and fibronectin in human placental villi has been studied by indirect immunofluorescence. During 9-12 weeks of pregnancy the extracellular matrix of villi represents a network of filaments organized in bundles and aggregates that contain collagen types I and III and finer filaments of collagen types IV and V.(More)
The placenta of 20 women with normal pregnancy was studied during II and III trimesters to obtain the complex characteristic of the structures participating in the formation of syncytio-capillary membranes. Immunocytochemical endothelial cell marker CD34 and morphometry were used for the assessment of some villous parameters: villous area, villous stromal(More)
Six basic mechanisms facilitating development of chronic placental deficiency, hypotrophy and fetal death are distinguished: 1) insufficiency of invasion of the extra-villous cytotrophoblast into the placental bed resulting in incomplete gestational restructuring of spiral arteries and reduction of uteroplacental circulation; 2) rheological disturbances in(More)
The extracellular matrix of perivillous fibrinoid in normal human term placenta was investigated by means of the indirect immunofluorescent technique. Polyclonal antibodies to collagen types I, III, IV, V, fibronectin, fibrinogen, laminin, entactin and heparan sulphate proteoglycan and monoclonal antibodies BC-1, IST-9 and IST-4 to human fibronectin were(More)
OBJECTIVE To estimate the intensity of immunoexpression of matrix metalloproteinases type 2 and type 9 (MMP-2 and MMP-9) during cytotrophoblast invasion (CTI) in the uteroplacental region. MATERIALS AND METHODS There were 6 groups: 1) medical abortions at 7 to 8 weeks' gestation; 2) amputated uteri at 9 to 12 weeks; 3) late medical abortions at 18 to 24(More)
PROBLEM Morphologic changes in the placental barrier in spontaneous early abortions under the maternal-embryonic immune conflict, and the role of maternal immunoglobulins (Igs) in these changes. MATERIALS AND METHODS We examined chorionic villi and other tissues obtained from 54 aborts between weeks 3.5 and 8 of pregnancy. Material was divided into two(More)