Andrey I. Kozlov

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Detailed population data were obtained on the distribution of novel biallelic markers that finely dissect the human Y-chromosome haplogroup E-M78. Among 6,501 Y chromosomes sampled in 81 human populations worldwide, we found 517 E-M78 chromosomes and assigned them to 10 subhaplogroups. Eleven microsatellite loci were used to further evaluate subhaplogroup(More)
BACKGROUND Genetic variation at NAT2 has been long recognized as the cause of differential ability to metabolize a wide variety of drugs of therapeutic use. Here, we explore the pattern of genetic variation in 12 human populations that significantly extend the geographic range and resolution of previous surveys, to test the hypothesis that different dietary(More)
We typed 1801 males from 55 locations for the Y-specific binary markers YAP, DYZ3, SRY10831 and the (CA)n microsatellites YCAII and DYS413. Phylogenetic relationships of chromosomes with the same binary haplotype were condensed in seven large one-step networks, which accounted for 95% of all chromosomes. Their coalescence ages were estimated based on(More)
Allele and genotype frequencies for the locus encoding apolipoprotein E, involved in the regulation of lipid metabolism (APOE), were evaluated in 16 populations representing 12 ethnic groups (a total of 1103 subjects) from Russia and neighboring countries. In the populations examined, the frequencies of allele ɛ4, which is the risk factor of Alzheimer’s(More)
The relationship between the vitamin D receptor gene (VDR) variants with serum 25-OHD3 concentration, body height (BH), body weight (BW), and body composition were examined in the Komi ethnic group. The FF-genotype was associated with higher BW (p = 0.002) and lower bone mass (BM, p = 0.06) in comparison to the Ff-genotype carriers. The BB-genotype carriers(More)
In this work we focus on a microsatellite-defined Y-chromosomal lineage (network 1.2) identified by us and reported in previous studies, whose geographic distribution and antiquity appear to be compatible with the Neolithic spread of farmers. Here, we set network 1.2 in the Y-chromosomal phylogenetic tree, date it with respect to other lineages associated(More)
BACKGROUND A growing number of reports describe markers with high frequencies of the ancestral alleles in Africa, contrasting with high frequencies and possibly fixation of derived variants out of Africa. Such a pattern can be explained by either neutral or non-neutral processes. AIM The study examined worldwide frequencies of two non-synonymous variants(More)
Fluctuating asymmetry (FA) is defined as random deviations from bilateral symmetry of the body. Thus, its magnitude is often used to evaluate developmental homeostasis. In this study we evaluate the following hypotheses: 1) FA of dermatoglyphic traits has a significant genetic component; 2) prenatal maternal environment (PME) has a significant effect on the(More)
The review considers the roles cortisol (Crt), dehydroepiandrosterone (DHEA), and DHEA sulfate (DHEA-S) play in the stress response. Age-related, sex-related, and circadian fluctuations in normal conditions and in acute or chronic stress are described for Crt, DHEA, and DHEA-S. The main techniques used to estimate the Crt level in the blood, urine, and(More)
Normally, the ability to digest milk sugar (lactose) is present in every child, but not in every adult. The decrease in lactase synthesis (hypolactasia) results in the inability to digest whole milk. Recent studies of the Finnish population have associated lactase persistence in adults with allele T of the C/T−13910 polymorphism located upstream of the(More)