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Bioavailability of rifampicin in 150 mg capsules manufactured by 5 different companies was studied. Conditions for investigation of the rate of the antibiotic transfer into solution with the use of the "Rotating Basket" apparatus were determined and statistically significant differences were found. The drugs also differed in the level and rate of antibiotic… (More)
The main principles in preparation of national standards of the antibiotics manufacture in the USSR are compared with those of the World Health Organization. The characteristics of preparing standards of mono- and multicomponent antibiotics, as well as the requirements for optimal packing of the standards are presented.
Bioavailability of various ampicillin dosage forms was studied. No difference in the level and rate of the antibiotic absorption was observed with the use of ampicillin trihydrate and anhydrous ampicillin capsules and ampicillin trihydrate tablets. Significant differences in the rate of ampicillin transfer into solution from various dosage forms were noted… (More)