Andrew Z. Wang

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Nucleic acid ligands, also known as aptamers, are a class of macromolecules that are being used in several novel nanobiomedical applications. Aptamers are characterized by high affinity and specificity for their target, a versatile selection process, ease of chemical synthesis and a small physical size, which collectively make them attractive molecules for(More)
Many liquid tumors (lymphomas and leukemias) have characteristic genomic alterations that are critical to their disease development and progression. For example, greater than 90% of the chronic myelogenous leukemias (CML) are caused by the t(9;22)(q34;q11) or BCR/ABL trans-location, whereas more than 75% of mantle cell lymphomas have the Because these(More)
Segmenting male pelvic organs from CT images is a prerequisite for prostate cancer radiotherapy. The efficacy of radiation treatment highly depends on segmentation accuracy. However, accurate segmentation of male pelvic organs is challenging due to low tissue contrast of CT images, as well as large variations of shape and appearance of the pelvic organs.(More)
Platinum-based chemotherapy, such as cisplatin, oxaliplatin, and carboplatin, is one of the most widely utilized classes of cancer therapeutics. While highly effective, the clinical applications of platinum-based drugs are limited by their toxicity profiles as well as suboptimal pharmacokinetic properties. Therefore, one of the key research areas in(More)
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