Andrew Young

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Stem cells resident in adult tissues are principally quiescent, yet harbor enormous capacity for proliferation to achieve self renewal and to replenish their tissue constituents. Although a single hematopoietic stem cell (HSC) can generate sufficient primitive progeny to repopulate many recipients, little is known about the molecular mechanisms that(More)
Genomic rearrangements of chromosome 15q11-q13 cause diverse phenotypes including autism, Prader-Willi syndrome (PWS), and Angelman syndrome (AS). This region is subject to genomic imprinting and characterized by complex combinations of low copy repeat elements. Prader-Willi and Angelman syndrome are caused primarily by 15q11-13 deletions of paternal and(More)
UNLABELLED Gene Ontology (GO) annotations have become a major tool for analysis of genome-scale experiments. We have created OntologyTraverser--an R package for GO analysis of gene lists. Our system is a major advance over previous work because (1) the system can be installed as an R package, (2) the system uses Java to instantiate the GO structure and the(More)
We present the results of a broadband simultaneous campaign on the nearby low-luminosity active galactic nucleus M81*. From February through August 2005, we observed M81* five times using the Chandra X-ray Observatory with the High-Energy Transmission Grating Spectrometer, complemented by groundbased observations with the Giant Meterwave Radio Telescope,(More)
A review of the literature reveals that while parallel computing is sometimes employed by astronomers for custom, large-scale calculations, no package fosters the routine application of parallel methods to standard problems in astronomical data analysis. This paper describes our attempt to close that gap by wrapping the Parallel Virtual Machine (PVM) as a(More)
Given a digraph D, let δ(D) := min{δ(D), δ−(D)} be the minimum semi-degree of D. D is k-ordered Hamiltonian if for every sequence s1, . . . , sk of distinct vertices of D there is a directed Hamilton cycle which encounters s1, . . . , sk in this order. Our main result is that every digraph D of sufficiently large order n with δ(D) ≥ ⌈(n+k)/2⌉−1 is k-ordered(More)
Mader conjectured that for all ` there is an integer δ(`) such that every digraph of minimum outdegree at least δ(`) contains a subdivision of a transitive tournament of order `. In this note we observe that if the minimum outdegree of a digraph is sufficiently large compared to its order then one can even guarantee a subdivision of a large complete(More)
We describe two means by which XSTAR, a code which computes physical conditions and emission spectra of photoionized gases, has been parallelized. The first is pvm xstar, a wrapper which can be used in place of the serial xstar2xspec script to foster concurrent execution of the XSTAR command line application on independent sets of parameters. The second is(More)
The incidence of anaphylactic/anaphylactoid reactions has been reported to vary between 1 : 3500 and 1 : 20,000 cases with a mortality rate ranging from 3 to 9%. Clinical signs present as skin rash, urticaria, angioedema, bronchospasm, tachycardia, bradycardia, and hypotension. Rapid identification and treatment are crucial to overall patient prognosis, as(More)
Anesthetic management of elderly patients requires numerous physiological considerations. With aging, degenerative changes occur in the structure and functional capacity of tissues and organs. Typically, these patients experience clinical effects with lower doses of medication. Important considerations for the geriatric populations following anesthesia(More)