Andrew Yates

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Memory CD8 T cells, generated by natural pathogen exposure or intentional vaccination, protect the host against specific viral infections. It has long been proposed that the number of memory CD8 T cells in the host is inflexible, and that individual cells are constantly competing for limited space. Consequently, vaccines that introduce over-abundant(More)
Differentiation of uncommitted T cells into Th1 and Th2 subpopulations depends on both intracellular events controlling expression of transcription factors T-bet and GATA-3 and interactions between cells mediated by cytokines, particularly IL4 and IFNgamma. A great deal is known about the intracellular and extracellular events involved in Th1 and Th2 (Th)(More)
Heterogeneity in the parameters governing the spread of infectious diseases is a common feature of real-world epidemics. It has been suggested that for pathogens with basic reproductive number R(0)>1, increasing heterogeneity makes extinction of disease more likely during the early rounds of transmission. The basic reproductive number R(0) of the introduced(More)
Quantifying cell division and death is central to many studies in the biological sciences. The fluorescent dye CFSE allows the tracking of cell division in vitro and in vivo and provides a rich source of information with which to test models of cell kinetics. Cell division and death have a stochastic component at the single-cell level, and the probabilities(More)
Recent experimental advances have allowed the estimation of the in vivo rates of killing of infected target cells by cytotoxic T lymphocytes (CTL). We present several refinements to a method applied previously to quantify killing of targets in the spleen using a dynamical model. We reanalyse data previously used to estimate killing rates of CTL specific for(More)
BACKGROUND The asymptomatic phase of HIV infection is characterised by a slow decline of peripheral blood CD4(+) T cells. Why this decline is slow is not understood. One potential explanation is that the low average rate of homeostatic proliferation or immune activation dictates the pace of a "runaway" decline of memory CD4(+) T cells, in which activation(More)
One of the tasks a Clinical Decision Support (CDS) system is designed to solve is retrieving the most relevant and actionable literature for a given medical case report. In this work, we present a query reformulation approach that addresses the unique formulation of case reports, making them suitable to be used on a general purpose search engine.(More)
In this work, we emphasize how to merge and re-rank contextual suggestions from the open Web based on a user‟s personal interests. We retrieve relevant results from the open Web by identifying context-independent queries, combining them with location information, and issuing the combined queries to multiple Web search engines. Our learning to rank model(More)
Helper T (Th) cells are a crucial component of the adaptive immune system and are of fundamental importance in orchestrating the appropriate response to pathogenic challenge. They fall into two broad categories defined by the cytokines each produces. Th1 cells produce interferon- gamma and are required for effective immunity to intracellular bacteria,(More)
We automatically extract adverse drug reactions (ADRs) from consumer reviews provided on various drug social media sites to identify adverse reactions not reported by the United States Food and Drug Administration (FDA) but touted by consumers. We utilize various lexicons, identify patterns, and generate a synonym set that includes variations of medical(More)