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Wireless microsensor systems are used in a variety of civil and military applications. Such microsensors are required to operate for years from a small energy source. To minimize the energy dissipation of the sensor node, RF front-end circuitry must be designed based on system level optimization of the entire network. This paper presents several energy(More)
Extracellular vesicles (EVs), specifically exosomes and microvesicles (MVs), are presumed to play key roles in cell-cell communication via transfer of biomolecules between cells. The biogenesis of these two types of EVs differs as they originate from either the endosomal (exosomes) or plasma (MVs) membranes. To elucidate the primary means through which EVs(More)
Magnetic iron oxide (IO) nanoparticles with a long blood retention time, biodegradability and low toxicity have emerged as one of the primary nanomaterials for biomedical applications in vitro and in vivo. IO nanoparticles have a large surface area and can be engineered to provide a large number of functional groups for cross-linking to tumor-targeting(More)
The design of wireless microsensor systems has gained increasing importance for a variety of civil and military applications. With the objective of providing short-range connectivity with significant fault tolerance, these systems find usage in such diverse areas as: environmental monitoring, industrial process automation, and field surveillance. The main(More)
The elucidation of factors that activate the regeneration of the adult mammalian heart is of major scientific and therapeutic importance. Here we found that epicardial cells contain a potent cardiogenic activity identified as follistatin-like 1 (Fstl1). Epicardial Fstl1 declines following myocardial infarction and is replaced by myocardial expression.(More)
This paper presents and validates a non-linear image registration method driven by points and curved landmarks using implicit representation. This approach produces smooth one-to-one mappings between topologically equivalent images by constraining the transformations to adhere to continuum mechanical laws. In this paper, the elastic operator is used for(More)
Antifouling magnetic iron oxide nanoparticles (IONPs) coated with block copolymer poly(ethylene oxide)-block-poly(γ-methacryloxypropyltrimethoxysilane) (PEO-b-PγMPS) were investigated for improving cell targeting by reducing nonspecific uptake. Conjugation of a HER2 antibody, Herceptin®, or a single chain fragment (ScFv) of antibody against epidermal growth(More)
We present experiments where the gating behavior of a voltage-gated ion channel is modulated by artificial ligand binding. We construct a channel-DNA chimera with the KvAP potassium channel reconstituted in an artificial membrane. The channel is functional and the single channel ion conductivity unperturbed by the presence of the DNA. However, the channel(More)