Learn More
In this paper we explore the issue of transforming models to models, an essential part of the OMG's Model Driven Architecture (MDA) vision. Drawing from the literature and our experiences implementing a number of transformations using different technologies, we explore the strengths and weaknesses of the different technologies and identify requirements for(More)
Applications are often designed to take advantage of the potential for integration with each other via shared information. Current approaches for integration are limited, effecting both the programmer and end-user. In this paper, we present CyberDesk, a framework for self-integrating software in which integration is driven by user context. It relieves the(More)
Gangliosides are key players in neuronal inhibition, with antibody-mediated clustering of gangliosides blocking neurite outgrowth in cultures and axonal regeneration post injury. In this study we show that the ganglioside GT1b can form a complex with the Nogo-66 receptor NgR1. The interaction is shown by analytical ultracentrifugation sedimentation and is(More)
Recent improvements in brain slice technology have made this biological preparation increasingly useful for examining pathophysiology of brain diseases in a tissue context. Brain slices maintain many aspects of in vivo biology, including functional local synaptic circuitry with preserved brain architecture, while allowing good experimental access and(More)
Pluripotent stem cell lines can be induced to differentiate into a range of somatic cell types in response to various stimuli. Such cell-based systems provide powerful tools for the investigation of molecules that modulate cellular development. For instance, the formation of the nervous system is a highly regulated process, controlled by molecular pathways(More)
Current software suites suffer from problems due to poor integration of their individual tools. They require the designer to think of all possible integrating behaviours and leave littIe flexibility to the user. CyberDesk is a component so&are fiamework that automatically integrates desktop and network services, reducing integrating decisions to be made by(More)
Because effective navigation in 3D virtual environments (VEs) depends on the specifics of the travel techniques and the display system, we compared two travel techniques (steering and target-based) and two display conditions—a high-fidelity setup (a four-wall display with stereo and head-tracking) and a lower-fidelity setup (a single wall display without(More)
Conservation of the vertebrate body plan has been attributed to the evolutionary stability of gene-regulatory networks (GRNs). We describe a regulatory circuit made up of Gata2, Fli1, and Scl/Tal1 and their enhancers, Gata2-3, Fli1+12, and Scl+19, that operates during specification of hematopoiesis in the mouse embryo. We show that the Fli1+12 enhancer,(More)
Huntington's disease (HD) is a late-onset, neurodegenerative disease for which there are currently no cures nor disease-modifying treatments. Here we report the identification of several potential anti-inflammatory targets for HD using an ex vivo model of HD that involves the acute transfection of human mutant huntingtin-based constructs into rat brain(More)