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We report the draft genome sequence of the model moss Physcomitrella patens and compare its features with those of flowering plants, from which it is separated by more than 400 million years, and unicellular aquatic algae. This comparison reveals genomic changes concomitant with the evolutionary movement to land, including a general increase in gene family(More)
In this paper we explore the issue of transforming models to models, an essential part of the OMG's Model Driven Architecture (MDA) vision. Drawing from the literature and our experiences implementing a number of transformations using different technologies, we explore the strengths and weaknesses of the different technologies and identify requirements for(More)
Applications are often designed to take advantage of the potential for integration with each other via shared information. Current approaches for integration are limited, effecting both the programmer and end-user. In this paper, we present CyberDesk, a framework for self-integrating software in which integration is driven by user context. It relieves the(More)
Gangliosides are key players in neuronal inhibition, with antibody-mediated clustering of gangliosides blocking neurite outgrowth in cultures and axonal regeneration post injury. In this study we show that the ganglioside GT1b can form a complex with the Nogo-66 receptor NgR1. The interaction is shown by analytical ultracentrifugation sedimentation and is(More)
Recent improvements in brain slice technology have made this biological preparation increasingly useful for examining pathophysiology of brain diseases in a tissue context. Brain slices maintain many aspects of in vivo biology, including functional local synaptic circuitry with preserved brain architecture, while allowing good experimental access and(More)
Pluripotent stem cell lines can be induced to differentiate into a range of somatic cell types in response to various stimuli. Such cell-based systems provide powerful tools for the investigation of molecules that modulate cellular development. For instance, the formation of the nervous system is a highly regulated process, controlled by molecular pathways(More)
Ischemic stroke is the second most common cause of death worldwide and a major cause of disability. Intravenous thrombolysis with rt-PA remains the only available acute therapy in patients who present within 3h of stroke onset other than the recently approved mechanical MERCI device, substantiating the high unmet need in available stroke therapeutics. The(More)
If immunized with an antigen of interest, transgenic mice with large portions of unrearranged human immunoglobulin loci can produce fully human antigen-specific antibodies; several such antibodies are in clinical use. However, technical limitations inherent to conventional transgenic technology and sequence divergence between the human and mouse(More)
Current software suites suffer from problems due to poor integration of their individual tools. They require the designer to think of all possible integrating behaviours and leave littIe flexibility to the user. CyberDesk is a component so&are fiamework that automatically integrates desktop and network services, reducing integrating decisions to be made by(More)