Andrew W. Roberts

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Upon ligand binding, RIPK1 is recruited to tumor necrosis factor receptor superfamily (TNFRSF) and Toll-like receptor (TLR) complexes promoting prosurvival and inflammatory signaling. RIPK1 also directly regulates caspase-8-mediated apoptosis or, if caspase-8 activity is blocked, RIPK3-MLKL-dependent necroptosis. We show that C57BL/6 Ripk1(-/-) mice die at(More)
Once more unto the breach, dear friends, once more, Or close the wall up with our English dead! In peace there's nothing so becomes a man As modest stillness and humility, But when the blast of war blows in our ears, Then imitate the action of the tiger: Stiffen the sinews, summon up the blood. Donald Metcalf—Professor Metcalf to those younger colleagues(More)
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