Andrew W Joseph

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The molecular basis of complex neuropsychiatric disorders most likely involves many genes. In recent years, specific genetic variations influencing risk for schizophrenia and other neuropsychiatric disorders have been reported. We have used custom DNA microarrays and qPCR to investigate the expression of putative schizophrenia susceptibility genes and(More)
Optimum extraction of energy from a wind turbine requires that turbine speed vary with wind speed. Existing solutions to produce constant-frequency electrical output under wind-speed variations are undesirable due to complexity, cost, inefficiency or reliability issues. We propose a novel variation of a doubly-fed induction generator which aims to improve(More)
This paper examines the role of retracted tongue root ([RTR]) harmony in Northeast Asian areal and genetic relationships. Recent research has suggested that at least three of the families grouped together as Altaic by Poppe (1960)-Korean, Mongolic, and Tungusic (KMT)-should be reconstructed with [RTRI vowel harmony. ln this paper we reinforce this(More)
Facial paralysis can result in serious ocular consequences. All patients with orbicularis oculi weakness in the setting of facial nerve injury should undergo a thorough ophthalmologic evaluation. The main goal of management in these patients is to protect the ocular surface and preserve visual function. Patients with expected recovery of facial nerve(More)
Here we describe the development of a novel specific, rapid ELISA system, which is performed on modified microplates where polyvinylidine fluoride (PVDF) forms the base of each well. The use of microplates with PVDF membranes as the solid phase allows for a greater binding capacity of protein in comparison to the solid phases of traditional ELISAs. The(More)
Copenhagen rats with implanted metastatic prostate carcinomas have been treated with the drug alpha-difluoromethylornithine (DFMO), an inhibitor of the enzyme ornithine decarboxylase. In vivo and in vitro 19F NMR observations were then carried out on a variety of organs and tissues. The distribution of the drug strongly favored tumor over surrounding(More)
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