Andrew W. George

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UNLABELLED Multiparent crosses of recombinant inbred lines provide opportunity to map markers and quantitative trait loci (QTL) with much greater resolution than is possible in biparental crosses. Realizing the full potential of these crosses requires computational tools capable of handling the increased statistical complexity of the analyses. R/mpMap(More)
There is a growing need for the development of statistical techniques capable of mapping quantitative trait loci (QTL) in general outbred animal populations. Presently used variance component methods, which correctly account for the complex relationships that may exist between individuals, are challenged by the difficulties incurred through unknown marker(More)
A fast, partly recursive deterministic method for calculating Identity-by-Descent (IBD) probabilities was developed with the objective of using IBD in Quantitative Trait Locus (QTL) mapping. The method combined a recursive method for a single marker locus with a method to estimate IBD between sibs using multiple markers. Simulated data was used to compare(More)
On extended pedigrees with extensive missing data, the calculation of multilocus likelihoods for linkage analysis is often beyond the computational bounds of exact methods. Growing interest therefore surrounds the implementation of Monte Carlo estimation methods. In this paper, we demonstrate the speed and accuracy of a new Markov chain Monte Carlo method(More)
An efficient whole genome method of QTL analysis is presented for Multi-parent advanced generation integrated crosses. Multi-parent advanced generation inter-cross (MAGIC) populations have been developed for mice and several plant species and are useful for the genetic dissection of complex traits. The analysis of quantitative trait loci (QTL) in these(More)
  • A W George, E A Thompson, Box, A t George, A Thompson
  • 2002
Multipoint linkage analyses of genetic data on extended pedigrees can involve exact computations which are infeasible. Markov chain Monte Carlo methods represent an attractive alternative, greatly extending the range of models and data sets for which analysis is practical. In this paper, several advances in Markov chain Monte Carlo theory, namely joint(More)
A Bayesian approach to the direct mapping of a quantitative trait locus (QTL), fully utilizing information from multiple linked gene markers, is presented in this paper. The joint posterior distribution (a mixture distribution modeling the linkage between a biallelic QTL and N gene markers) is computationally challenging and invites exploration via Markov(More)
For many years, genetic markers have been the building blocks in assembling genomic knowledge. Improved technology and methods for collecting marker data have increased accuracy, increased throughput, and reduced cost. However, common genotyping technology still produces far fewer markers in plant species than in animals and humans. We propose a new type of(More)
Chromosome doubling in megaspores of sugarcane was first reported over 70 years ago and was seen primarily in interspecific crosses between Saccharum officinarum and Saccharum spontaneum. Since then, there has been robust debate on the mechanism(s) responsible for this doubling with hypotheses ranging from second division restitution (SDR), post-meiotic(More)
The authors found that 12 (57%) of 21 consecutive male patients with borderline personality disorder who presented for psychiatric treatment at two distant geographic sites were homosexual. They then obtained the sexual histories of 80 patients who met standardized criteria for borderline disorder and found that 17 (21%) of these patients were homosexual,(More)