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BACKGROUND Decision curve analysis (DCA) has been proposed as an alternative method for evaluation of diagnostic tests, prediction models, and molecular markers. However, DCA is based on expected utility theory, which has been routinely violated by decision makers. Decision-making is governed by intuition (system 1), and analytical, deliberative process(More)
Inconsistencies may arise in the course of specification of systems, and it is now recognised that they cannot be forbidden. Recent work has concentrated on enabling requirements descriptions to tolerate inconsistency and on proposing notations that permit inconsistency in specifications. We approach the subject by examining the use of an existing causal(More)
β-glucans are complex, naturally-occurring polysaccharides that prime leukocyte dectin and complement receptor 3. Based on our preclinical findings, indicating that oral barley-derived (1 → 3),(1 → 4)-β-D-glucan (BG) synergizes with the murine anti-GD2 antibody 3F8 against neuroblastoma, we conducted a Phase I clinical study to evaluate the safety of this(More)
We have previously reported on coded aperture snapshot spectral imagers (CASSI) that can capture a full frame spectral image in a snapshot. Here we describe the use of CASSI for spectral imaging of a dynamic scene at video rate. We describe significant advances in the design of the optical system, system calibration procedures and reconstruction method. The(More)
Organisations are seeking to improve the way they undertake engineering activities. There are numerous ways of doing this, one of which is to undertake an ongoing process, or capability, enhancement activity. Praxis Critical Systems Limited provides support for such activity based primarily around the REVEAL ® requirements engineering method. By providing(More)
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