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Microsatellite Tandem Repeats Are Abundant in Human Promoters and Are Associated with Regulatory Elements
Tandem repeats are genomic elements that are prone to changes in repeat number and are thus often polymorphic. These sequences are found at a high density at the start of human genes, in the gene’sExpand
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Association of poly-purine/poly-pyrimidine sequences with meiotic recombination hot spots
BackgroundMeiotic recombination events have been found to concentrate in 1–2.5 kilo base regions, but these recombination hot spots do not share a consensus sequence and why they occur at specificExpand
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Evolution of Microsatellite DNA
Microsatellites are highly mutable nucleotide arrays composed of short motifs repeated in tandem. They are ubiquitously distributed in bacterial and eukaryotic genomes and their abundance andExpand
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Functional Mechanisms of Microsatellite DNA in Eukaryotic Genomes
Abstract Microsatellite repeat DNA is best known for its length mutability, which is implicated in several neurological diseases and cancers, and often exploited as a genetic marker. Less well-knownExpand
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The relationship between microsatellite polymorphism and recombination hot spots in the human genome.
Although previous studies have failed to detect an association between microsatellite polymorphism and broadscale recombination rates in the human genome, there are several possible reasons why suchExpand
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Promoter microsatellites as modulators of human gene expression.
Microsatellites in and around genes have been shown to modulate levels of gene expression in multiple organisms, ranging from bacteria to humans. Here we will discuss promoter microsatellites knownExpand
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The Accuracy, Feasibility and Challenges of Sequencing Short Tandem Repeats Using Next-Generation Sequencing Platforms
To date we have little knowledge of how accurate next-generation sequencing (NGS) technologies are in sequencing repetitive sequences beyond known limitations to accurately sequence homopolymers.Expand
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High frequency of microsatellites in S. cerevisiae meiotic recombination hotspots
BackgroundMicrosatellites are highly abundant in eukaryotic genomes but their function and evolution are not yet well understood. Their elevated mutation rate makes them ideal markers of geneticExpand
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The effects of transcription and recombination on mutational dynamics of short tandem repeats
Abstract Short tandem repeats (STR) are ubiquitous components of the genomic architecture of most living organisms. Recent work has highlighted the widespread functional significance of such repeats,Expand
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No Effect of Genome-Wide Copy Number Variation on Measures of Intelligence in a New Zealand Birth Cohort
Variation in human intelligence is approximately 50% heritable, but understanding of the genes involved is limited. Several forms of genetic variation remain under-studied in relation toExpand
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