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Effect of Antigenic Heterogeneity on the Efficacy of Enhanced Delivery of Antibody-targeted Chemotherapy in a Human Lung Cancer Intracerebral Xenograft Model in Rats
- E. Neuwelt, L. Thrun, S. Walker-Rosenfeld, Andrew T. Cave, L. Muldoon
- 1 December 2003
OBJECTIVEThe SGN-15 monoclonal antibody-doxorubicin immunoconjugate is toxic to LewisY antigen-expressing cells and is effective against intracerebral tumors in nude rats when delivery is enhanced… Expand