Andrew Sullivan

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Mesenchymal stem cells have been recently described to localize to breast carcinomas, where they integrate into the tumour-associated stroma. However, the involvement of mesenchymal stem cells (or their derivatives) in tumour pathophysiology has not been addressed. Here, we demonstrate that bone-marrow-derived human mesenchymal stem cells, when mixed with(More)
DNS64 is a mechanism for synthesizing AAAA records from A records. DNS64 is used with an IPv6/IPv4 translator to enable client-server communication between an IPv6-only client and an IPv4-only server, without requiring any changes to either the IPv6 or the IPv4 node, for the class of applications that work through NATs. This document specifies DNS64, and(More)
Novel methodology and algorithms to seamlessly integrate logic synthesis and physical placement through a transformational approach are presented. Contrary to most placement algorithms that minimize a global cost function based on an abstract representation of the design, we decomposed the placement function into a set of transforms and coupled them(More)
OBJECTIVE To analyze interactions between the thyroid-stimulating hormone receptor (TSHR) and a thyroid-stimulating human monoclonal autoantibody (M22) at the molecular level. DESIGN A complex of part of the TSHR extracellular domain (amino acids 1-260; TSHR260) bound to M22 Fab was prepared and purified. Crystals suitable for X-ray diffraction analysis(More)
Routability or wiring congestion in a very large scale integration chip is becoming increasingly important as chip complexity increases. Congestion has a significant impact on performance, yield, and chip area. Although advances in placement algorithms have attempted to alleviate this problem, the inherent structure of the logic netlist has a significant(More)
A complex of the TSH receptor extracellular domain (amino acids 22-260; TSHR260) bound to a blocking-type human monoclonal autoantibody (K1-70) was purified, crystallised and the structure solved at 1.9 Å resolution. K1-70 Fab binds to the concave surface of the TSHR leucine-rich domain (LRD) forming a large interface (2565 Å(2)) with an extensive network(More)
Routability or wiring congestion in a VLSI chip is becoming increasingly important as chip complexity increases. Congestion has a significant impact on performance, yield and chip area. Although advances in placement algorithms have attempted to alleviate this problem, the inherent structure of the logic netlist has a significant impact on the routability(More)
Achieving timing-closure has become one of the hardest tasks in logic synthesis due to the required stringent timing constraints in very large circuit designs. In this paper, we propose a novel synthesis paradigm to achieve timing-closure called Timing-Aware CUt Enumeration (TACUE). In TACUE, optimization is conducted through three aspects: (1) a new(More)
BACKGROUND Delayed-type β-lactam hypersensitivity develops in subset of patients. The cellular immunological processes that underlie the drug-specific response have been described; however, little is known about involvement of the humoral immune system. Thus, the aim of this study was to utilize piperacillin hypersensitivity as an exemplar to (i) develop(More)