Andrew Stone

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  • Maria Kalyuga, David Gallego-Ortega, Heather J. Lee, Daniel L. Roden, Mark J. Cowley, C. Elizabeth Caldon +24 others
  • 2012
We have previously shown that during pregnancy the E-twenty-six (ETS) transcription factor ELF5 directs the differentiation of mammary progenitor cells toward the estrogen receptor (ER)-negative and milk producing cell lineage, raising the possibility that ELF5 may suppress the estrogen sensitivity of breast cancers. To test this we constructed inducible(More)
Dysregulation of the epigenome is a common event in malignancy; however, deciphering the earliest cancer-associated epigenetic events remains a challenge. Cancer epigenome studies to date have primarily utilised cancer cell lines or clinical samples, where it is difficult to identify the initial epigenetic lesions from those that occur over time. Here, we(More)
—There is a significant, established code base in the scientific computing community. Some of these codes have been parallelized already but are now encountering scalability issues due to poor data locality, inefficient data distributions, or load imbalance. In this work, we introduce a new abstraction called loop chaining in which a sequence of parallel(More)
—Research on Internet routing algorithms can benefit greatly by easily repeatable large-scale simulations conducted on realistic network topologies. Unfortunately, it is a challenging task to develop clear and unambiguous definitions of a routing protocol and its associated policies. Simulations often only operate on small scale topologies. Even if(More)
The first stage in transitioning from stakeholders' needs to formal designs is the synthesis of user requirements from information elicited from the stakeholders. In this paper we show how shallow natural language techniques can be used to assist analysis of the elicited information and so inform the synthesis of the user requirements. We also show how(More)
In the present study, we have taken the novel approach of using an in vitro model representative of tamoxifen-withdrawal subsequent to clinical relapse to achieve a greater understanding of the mechanisms that serve to maintain the resistant-cell phenotype, independent of any agonistic impact of tamoxifen, to identify potential novel therapeutic approaches(More)
In this paper we present a design case study using DG2VHDL, a tool which bridges the gap between an abstract graphical description of a DSP algorithm and its concrete hardware description language (HDL) representation. DG2VHDL automatically translates a Dependence Graph (DG) 1] into a synthesizable, behavioral VHDL entity that can be input to industrial(More)
Epigenetic alterations in the cancer methylome are common in breast cancer and provide novel options for tumour stratification. Here, we perform whole-genome methylation capture sequencing on small amounts of DNA isolated from formalin-fixed, paraffin-embedded tissue from triple-negative breast cancer (TNBC) and matched normal samples. We identify(More)